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Genomics of Hairy Cell Leukemia
Journal of Clinical Oncology, 2017 Hairy cell leukemia (HCL) is a chronic mature B-cell neoplasm with unique clinicopathologic features and an initial exquisite sensitivity to chemotherapy with purine analogs; however, the disease relapses, often repeatedly. The enigmatic pathogenesis of HCL was recently clarified by the discovery of its underlying genetic cause, the BRAF-V600E kinase ...
TIACCI, Enrico +3 more
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The Liver in Hairy Cell Leukemia
Annals of Internal Medicine, 1980 Excerpt To the editor: The clinical review of Golumb, Catovsky, and Golde (1), based on 71 cases of hairy cell leukemia, stresses its clinical and laboratory characteristics and the prognostic fact...
GEORGOULIAS, V +3 more
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Medicine, 1978 Hairy cell leukemia is a chronic but steadily progressive malignancy usually of older males. Clinically, patients present with splenomegaly and/or cytopenia. The diagnosis is made by demonstration of the hairy cell in Wright's-stained peripheral blood and in bone marrow and by the characteristic histologic findings in the bone marrow biopsy and spleen ...
A, Turner, C R, Kjeldsberg
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A Case Report of Hairy Cell Leukemia Presenting Concomitantly with Sweet Syndrome
Case Reports in Medicine, 2014 Hairy cell leukemia and Sweet syndrome are both uncommon hematological diagnoses. We present a patient who was admitted with fevers, pancytopenia, pneumonia, and rash.
Mohammad Alkayem, Waina Cheng
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Case Reports in Oncology, 2018 The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer.
Maria Mitsogianni +6 more
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Infections in hairy-cell leukemia [PDF]
Blood, 1978 Abstract In order to determine the nature of infectious complications in hairy-cell leukemia we studied 20 consecutive patients seen at UCLA and analyzed the available literature. The incidence of serious infection in our series was 40%, and pneumonia and septicemia due to Pseudomonas and E.
E, Bouza, C, Burgaleta, D W, Golde
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BRAF V600E-Negative Hairy Cell Leukaemia
Case Reports in Hematology, 2013 Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease.
Stephen E. Langabeer +4 more
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«White spleen» in hairy cell leukemia
Клінічна хірургія, 2019 «White spleen» in hairy cell ...
V. M. Milosavljević +4 more
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FEBS Open Bio, EarlyView.Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar +11 more
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Journal of Applied Hematology, 2015 Plasma cell leukemia (PCL) is defined by the presence of more than 2 × 109/L PCs in the peripheral blood. It is a very rare type of leukemia with poor outcome. In this case, we report a PCL case with peripheral blood morphology of hairy cell leukemia. We
Nahlah Alghasham +3 more
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