Results 121 to 130 of about 52,777 (274)

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

Best practices in surgical and nonsurgical management of head and neck Merkel cell carcinoma: An update

Molecular Carcinogenesis, Volume 62, Issue 1, Page 101-112, January 2023., 2023
Abstract Merkel cell carcinoma (MCC) is a rare, highly aggressive cutaneous neuroendocrine carcinoma. Controversy exists regarding optimal management of MCC as high‐quality randomized studies and clinical trials are limited, and physicians are bound to interpret highly heterogeneous, retrospective literature in their clinical practice. Furthermore, the
Daniela Duarte‐Bateman, Alan Shen, Taylor Bullock, Payam Sadeghi, Joseph M. Escandón, Eliska Dedkova, Brian R. Gastman   +6 more
wiley   +1 more source

ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study

Hematology, Transfusion and Cell Therapy, 2018
Background: Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells ...
Rodolfo Patussi Correia, Flávia Amoroso Matos e Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo Pessini Amarante-Mendes   +5 more
doaj  

Periodic Oscillations of Blood Cell Populations in Chronic Myelogenous Leukemia [PDF]

arXiv, 2004
We develop some techniques to prove analytically the existence and stability of long period oscillations of stem cell populations in the case of periodic chronic myelogenous leukemia. Such a periodic oscillation $p_\infty $ can be analytically constructed when the hill coefficient involved in the nonlinear feedback is infinite, and we show it is ...
arxiv  

Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates

Cancer Immunology, Immunotherapy
AbstractChronic lymphocytic leukemia (CLL) is a disease of the elderly, often presenting comorbidities like osteoporosis and requiring, in a relevant proportion of cases, treatment with bisphosphonates (BPs). This class of drugs was shown in preclinical investigations to also possess anticancer properties. We started an in vitro study of the effects of
Mazzarello, Andrea N., Gugiatti, Elena, Cossu, Vanessa, Bertola, Nadia, Bagnara, Davide, Carta, Sonia, Ravera, Silvia, Salvetti, Chiara, Ibatici, Adalberto, Ghiotto, Fabio, Colombo, Monica, Cutrona, Giovanna, Marini, Cecilia, Sambuceti, Gianmario, Fais, Franco, Bruno, Silvia   +15 more
openaire   +4 more sources

Diagnosis of Malignant Lymphoma Cancer Using Hybrid Optimized Techniques Based on Dense Neural Networks [PDF]

arXiv
Lymphoma diagnosis, particularly distinguishing between subtypes, is critical for effective treatment but remains challenging due to the subtle morphological differences in histopathological images. This study presents a novel hybrid deep learning framework that combines DenseNet201 for feature extraction with a Dense Neural Network (DNN) for ...
arxiv  

Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

Revista Brasileira de Hematologia e Hemoterapia
Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+.
Celso Arrais Rodrigues, Matheus Vescovi Gonçalves, Maura Rosane Valério Ikoma, Irene Lorand-Metze, André Domingues Pereira, Danielle Leão Cordeiro de Farias, Maria de Lourdes Lopes Ferrari Chauffaille, Rony Schaffel, Eduardo Flávio Oliveira Ribeiro, Talita Silveira da Rocha, Valeria Buccheri, Yuri Vasconcelos, Vera Lúcia de Piratininga Figueiredo, Carlos Sérgio Chiattone, Mihoko Yamamoto   +14 more
doaj   +1 more source

Mathematical model of CAR-T-cell therapy for a B-cell Lymphoma lymph node [PDF]

arXiv
CAR-T cell therapies have demonstrated significant success in treating B-cell leukemia in children and young adults. However, their effectiveness in treating B-cell lymphomas has been limited. Unlike leukemia, lymphoma often manifests as solid masses of cancer cells in lymph nodes, glands, or organs, making these tumors harder to access thus hindering ...
arxiv