Results 101 to 110 of about 17,826,638 (304)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Role of ofatumumab in treatment of chronic lymphocytic leukemia [PDF]

, 2011
Marays Veliz, Javier Pinilla-IbarzH Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USAAbstract: The management of chronic lymphocytic leukemia (CLL) has dramatically improved in the past decade with the addition of anti-CD20 monoclonal ...
Pinilla-Ibarz J, Javier Pinilla-Ibarz, null Veliz, Veliz M   +3 more
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC [PDF]

, 2012
PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
John G. Gribben, Xing, D, Halpert Matthew M., Shpall, EJ, John G Gribben, Keating Michael J., Yang, H, Hong Yang, Halpert, MM, Elizabeth J Shpall, William K. Decker, Elizabeth J. Shpall, Li Sufang, Gribben John G., Michael J. Keating, Molldrem Jeffrey J., Lapushin Ruth, Lapushin, R, Xing Dongxia, Parmar Simrit, Robinson Simon N., Parmar, S, Simrit Parmar, Shpall Elizabeth J., Yang Hong, William K Decker, Wierda, WG, Shah Nina, Shah, N, William G Wierda, Gribben, JG, Sufang Li, Dongxia Xing, Matthew M Halpert, Jeffrey J Molldrem, Simon N. Robinson, Simon N Robinson, William G. Wierda, Michael J Keating, Matthew M. Halpert, Robinson, SN, Molldrem, JJ, Decker William K., Keating, MJ, Ruth Lapushin, Jeffrey J. Molldrem, Decker, WK, Wierda William G., Li, S, Nina Shah   +49 more
core   +2 more sources

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Adhesion molecule profiles of B-cell non-Hodgkin's lymphomas in the leukemic phase

Brazilian Journal of Medical and Biological Research, 2006
We evaluated the expression of 10 adhesion molecules on peripheral blood tumor cells of 17 patients with chronic lymphocytic leukemia, 17 with mantle-cell lymphoma, and 13 with nodal or splenic marginal B-cell lymphoma, all in the leukemic phase and ...
D.M. Matos, E.G. Rizzatti, A.B. Garcia, D.A.P. Gallo, R.P. Falcão   +4 more
doaj  

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Immune Complexes and Apoptosis in B-cell Chronic Lymphocytic Leukemia

Leukemia & Lymphoma, 2002
The progressive accumulation of B-cell chronic lymphocytic leukemia (B-CLL) cells in vivo is attributed to resistance to apoptosis, although this can be modulated in vitro by a variety of cellular and humoral factors (cell-cell, cell-matrix interactions, cytokines).
Gamberale, Romina, Geffner, Jorge Raúl, Giordano, Mirta Nilda   +2 more
openaire   +3 more sources

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Biclonal Gammopathy in Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

Oman Medical Journal, 2015
Monoclonal gammopathies are frequently seen in B-cell malignancies. Monoclonal proteins are seen in a significant proportion of patients with chronic lymphocytic leukemia (CLL), which is a clonal disorder of mature B cells.
Nafila Al-Riyami, Khalil Al-Farsi, Khalfan Al-Amrani, Sameera Al-Harrasi, Mohammed Al-Huneini, Salam Al-Kindi   +5 more
doaj   +1 more source