Results 131 to 140 of about 102,788 (290)

Diagnosis and treatment of chronic lymphocytic leukemia: 2025 recommendations of the Brazilian Group of Chronic Lymphocytic Leukemia of the Brazilian Association of Hematology and Hemotherapy (ABHH)

Hematology, Transfusion and Cell Therapy
Chronic lymphocytic leukemia, characterized by an accumulation of monoclonal B lymphocytes, is the most common adult leukemia. The disease predominantly affects older adults, with a significant proportion being asymptomatic at diagnosis.
Carlos Sérgio Chiattone, Fernanda de Morais Marques, Valeria Buccheri, Mihoko Yamamoto, Sergio Costa Fortier, Maura Rosane Valerio Ikoma-Colturato, Nelson Hamerschlak, Vera Lucia de Piratininga Figueiredo, Talita Maira Bueno da Silveira, Abel Costa, Dani Laks, Rony Schaffel, Wolney Gois Barreto, Adriana Scheliga, Pedro Amoedo Fernandes, Samir Kanaan Nabhan, Rafael Dezen Gaiolla, Matheus Vescovi Gonçalves, Danielle Leão Cordeiro de Farias, Glaciano Ribeiro, Marcelo Pitombeira de Lacerda, Celso Arrais-Rodrigues   +21 more
doaj   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy

Advanced Science, EarlyView.
This review summarizes recent advances in cGAS‐STING agonist‐based nanotherapeutics for cancer combination therapy. It explores nanoparticle‐mediated delivery strategies, underlying molecular mechanisms, and combinatorial applications with chemotherapy, radiotherapy, targeted therapy, phototherapy, sonodynamic therapy, and immunotherapy.
Zhaomeng Wang, Yongjun Wang, Zhonggui He, Caigang Liu   +3 more
wiley   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

High fludarabine exposure and relationship with treatment-related mortality after nonmyeloablative hematopoietic cell transplantation. [PDF]

, 2011
Despite its common use in nonmyeloablative preparative regimens, the pharmacokinetics of fludarabine are poorly characterized in hematopoietic cell transplantation (HCT) recipients and exposure-response relationships remain undefined.
Brunstein, CG, Cao, Q, Green, KG, Jacobson, PA, Long-Boyle, JR, McGlave, PB, Miller, JS, Rogosheske, J, Wagner, JE, Weisdorf, DJ   +9 more
core   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

Microenvironmental Influences and Antigenic Stimulation in Chronic Lymphocytic Leukemia [PDF]

, 2009
Hiddemann, Wolfgang, Seiler, Till
core   +1 more source

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies [PDF]

, 2010
Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but ...
Akasaka, T. (T.), Ammerpohl, O. (Ole), Callet-Bauchu, E. (E.), Dyer, M.J.S. (Martin J. S.), Gascoyne, R.D (R. D.), Gesk, S. (Stefan), Harder, L. (Lana), Horsman, D. (D.), Klapper, W. (Wolfram), Majid, A. (Aneela), Martin-Subero, J.I. (Jose Ignacio), Martinez-Climent, J.A. (José Ángel), Nagel, I. (Inga), Siebert, R. (Reiner), Stilgenbauer, S. (Stepahn), Szczepanowski, M. (Monika), Tönnies, H. (Holger)   +16 more
core  

Rheumatoid arthritis and B-cell chronic lymphocytic leukemia.

Clinical and experimental rheumatology, 2002
The association between lymphoproliferate malignancies, especially lymphoma, and rheumatoid arthritis (RA) has been confirmed by several studies. However; there are few reports of RA patients who developed B-cell chronic lymphocytic leukemia (B-CLL) and vice versa. We report a patient with B-CLL who developed RA and another with RA who presented with B-
Voulgari, P. V., Vartholomatos, G., Kaiafas, P., Bourantas, K. L., Drosos, A. A.   +4 more
openaire   +2 more sources

Mucosal‐Associated Invariant T Cells in Rheumatic Diseases

Arthritis &Rheumatology, EarlyView.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source