Results 181 to 190 of about 76,259 (245)

Clonal Hematopoiesis: Impact on Health and Disease. [PDF]

Hematol Oncol
Caiado F, Manz MG.
europepmc   +1 more source

Sketching T cell atlases in the single‐cell era: challenges and recommendations

Immunology &Cell Biology, EarlyView.
Recent advances in single‐cell technologies have enabled the creation of T cell atlases, providing detailed maps of adaptive immunity across tissues, development and disease states. These atlases help uncover T cell diversity, functional states and disease mechanisms, aiding in the identification of therapeutic targets.
Itana Bojović, António GG Sousa, Sini Junttila, Laura L Elo   +3 more
wiley   +1 more source

Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8+ Cells and TNF‐α Levels in Target Organs, and Protects Mice From Graft‐Versus‐Host Disease‐Related Mortality Through PPAR Activation Without Compromising the Graft‐Versus‐Tumour Response

Immunology, EarlyView.
Effect of Palmitoylethanolamide (PEA) in a murine model of graft‐versus‐host disease (GVHD). Following an allogeneic transplant from C57BL/6J donors to BALB/c recipients, PEA treatment improved survival, alleviated clinical symptoms, and protected target organs in GVHD‐affected mice.
Bárbara Betônico Berg, Zara Desiree Tonidandel Campos, Gioconda Muniz Fiorenza Ruggio, Ana Flávia Santos Linhares, Bárbara Maximino Rezende, Stêfany Bruno de Assis Cau, Thiago Roberto Lima Romero, Mauro Martins Teixeira, Vanessa Pinho, Marina Gomes Miranda Castor   +9 more
wiley   +1 more source

Case report: single-cell transcriptome sequencing reveals the clonal origin of mature plasmacytoid dendritic cell proliferation in early T-cell precursor lymphoblastic leukemia. [PDF]

Ann Hematol
Zhang L, Lu Y, Jiang J, Wu G.
europepmc   +1 more source

Lichenoid graft‐versus‐host disease shows a high interferon score, with IFNAR1 inhibition preventing skin inflammation

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This study identifies interferons as key mediators in lichenoid chronic GVHD pathogenesis, along with Th2 and Th17 involvement. It particularly highlights the role of Type I interferon, showing that early anti‐IFNAR1 treatment reduces skin inflammation in a murine model of chronic cutaneous GVHD.
Chloé Grolleau, Thomas Poisot, Andreea Calugareanu, Regis Peffault De Latour, Marie Robin, David Michonneau, Flore Sicre de Fontbrune, Adèle de Masson, Maxime Battistella, Gerard Socié, Hélène Le Buanec, Jean‐David Bouaziz   +11 more
wiley   +1 more source

Diagnostic approach to leukemia cutis : A differential diagnostic step-by-step algorithm. [PDF]

Am J Clin Pathol
Jenei A, Tzankov A.
europepmc   +1 more source

Gaucher disease, state of the art and perspectives

Journal of Internal Medicine, EarlyView.
Abstract Knowledge about Gaucher disease (GD), considered a model for rare diseases, has considerably increased since its discovery. The pathophysiology of this lysosomal disorder is better known, and specific therapies that can control many aspects of the disease have been developed, particularly for the most common form, Type 1 GD.
Fabrice Camou, Marc G. Berger
wiley   +1 more source

The reprogramming factor KLF4 in normal and malignant blood cells. [PDF]

Front Immunol
Lacorazza HD.
europepmc   +1 more source

Precision oncology to overcome resistance in R/R AML in children and adults requires combinations of cytotoxic, targeted, and immunological treatments

Journal of Internal Medicine, EarlyView.
Abstract Although outcomes for newly diagnosed acute myeloid leukaemia (AML) have been incrementally improved over the last decades, management of relapsed and refractory (R/R) AML remains a medical challenge. A curative intent for R/R AML usually involves chemotherapy (with or without targeted therapy) with subsequent consolidation, including ...
Martin Jädersten, Ingrid Lilienthal, Christer Nilsson, Louisa Fredrikson, Cornelis Jan Pronk, Kristian Løvvik Juul‐Dam, Mika Kontro, Nikolas Herold   +7 more
wiley   +1 more source