Results 181 to 190 of about 713,469 (335)

Optimizing Ibrutinib Posology in Chronic Lymphocytic Leukemia Using a Semi‐Mechanistic Pharmacometric Framework

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Ibrutinib, a Bruton's tyrosine kinase (Btk) inhibitor, is a key therapy for chronic lymphocytic leukemia (CLL). In clinical practice, adverse events, such as hypertension, frequently necessitate dose reductions or treatment discontinuation. Emerging evidence suggests that reduced doses may retain clinical efficacy while mitigating toxicity ...
Eman I. K. Ibrahim, Lena E. Friberg
wiley   +1 more source

Novel Diffuse Midline Glioma‐on‐Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies

Small, EarlyView.
In this work, a DMG‐on‐Chip (DoC) is set up, with a geometry yielding gradients of nutrient and oxygen depletion, to recapitulate this trait of tumor microenvironment‐driven heterogeneity. The biophysical and biochemical characterization of this microsystem via fluorescence microscopy analyses highlights the acidification of the tumor core, along with ...
Lisa Terrassoux, Calypso Hazard, Agathe Laratte, Joanne Balsamelli, Mélanie Arcicasa, Elisa Fong, Léo Baland, Fabrice Soncin, Giovanni Cappello, Claude‐Alain Maurage, Sebastien Janel, Antony Bazir, Fabrizio Cleri, Anthony Treizebre, Eric Lartigau, Yousr Rekik, Samuel Meignan, Alessandro Furlan   +17 more
wiley   +1 more source

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia.

Blood, 2015
R. Somasundaram, M. Prasad, Jonas Ungerbäck, M. Sigvardsson   +3 more
semanticscholar   +1 more source

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, EarlyView.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

Mortality Trends and Demographic Disparities Among Patients With Lymphoid Leukemia and Septicemia. [PDF]

Cureus
Undhad H, Joshi P, Patil N, Uppal N, Bedi S.   +4 more
europepmc   +1 more source

Bilateral Periareolar Nodules in an Adolescent With a History of Lymphoma

JEADV Clinical Practice, EarlyView.
Rawan Almutairi, Mohamed Saad, Hamad Alajmi, Ali Alajmi, Humoud Al‐Sabah, Atlal Allafi   +5 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Inmunofenotipaje celular en el diagnostico de la leucemia mieloide aguda Cellular immunophenotyping in the diagnosis of acute myeloid leukemia

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2005
The immunophenotype of the leukemic cells was analyzed in 72 patients with diagnosis of acute myeloid leukemia (AML) that received attention at the Institute of Hematology and Immunology during 13 years. The cellular immunophenotyping (CIP) was performed
doaj  

Middle East Deployment and Lymphoid Malignancies in US Veterans: A Matched Case-Control Analysis. [PDF]

Cancers (Basel)
Ma H, Gupta P.
europepmc   +1 more source