Results 191 to 200 of about 388,053 (254)

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

Therapeutic success and epidemiological failure in hematology. [PDF]

Hemasphere
Sujobert P.
europepmc   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

The critical role of flow cytometry in diagnosing aberrant T-cell acute lymphoblastic leukemia in a dog: case report. [PDF]

Front Vet Sci
Bitencourt RC, da Silva FR, de Oliveira LCCC, Crippa GH, de Nardi AB.   +4 more
europepmc   +1 more source

SLV‐404, an anti‐RYK antibody–drug conjugate, is effective in Richter transformation patient‐derived xenografts

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract Richter transformation (RT), a highly aggressive lymphoma arising from a preexisting chronic lymphocytic leukemia, represents a major unmet clinical need. Recent data have shown that an antibody–drug conjugate (ADC) targeting the cell‐surface pseudokinase ROR1 is effective in RT patients.
Matilde Micillo, Beatrice Pirajno, Francesco Edoardo Vallone, Victor Navarro‐Tableros, Elisabetta Bolli, Valentina Griggio, Brian J. Lannutti, Katti A. Jessen, Tiziana Vaisitti, Silvia Deaglio   +9 more
wiley   +1 more source

Spatiotemporal analysis and socioeconomic determinants of pediatric lymphoid leukemias mortality in Brazil from 2000 to 2021: an ecological study. [PDF]

Lancet Reg Health Am
Sanches BS, Oliveira IL, Botelho CDE, Duarte NL, Berger U, Land MGP.   +5 more
europepmc   +1 more source

Myeloid/Lymphoid Neoplasm with FGFR1::ZMYM2 Rearrangement Presenting as T-Cell Acute Lymphoblastic Lymphoma with Concurrent Myeloproliferative Neoplasm: A Case Report. [PDF]

Hematol Rep
Krishnareddigari M, Patel G, Bokhari A, Graff JP, Dwyre DM, Panigrahi A.   +5 more
europepmc   +1 more source

Mixed phenotype acute leukemia mimicking adult-onset Still's disease in a pregnant female: A rare case report. [PDF]

Medicine (Baltimore)
Abedeen ZU, Ghani MZ, Ambreen U, Ullah Z, Saleem S, Ashraf U, Fatima M, Baig R, Rehman AU.   +8 more
europepmc   +1 more source

Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Somatic mitochondrial–nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours. Methods EuroClonality‐NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for ...
James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V. Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W. Langerak, David Gonzalez   +9 more
wiley   +1 more source

Diagnostic Concordance and Superiority of Flow Cytometry Over Immunohistochemistry in Acute Leukemia Immunophenotyping: A Single-Center Study. [PDF]

Med Sci Monit
Dağlıoğlu G, Toyran T, Öztürk ÖG, Binokay H, Kibar F, Çetiner S, Türkmen TP, Gürkan E, Şaşmaz Hİ, Tanrıkulu F, Özkan A, Ergin M, Şener M, İnal TC.   +13 more
europepmc   +1 more source