Results 211 to 220 of about 388,053 (254)

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

High-dimensional spectral flow cytometry uncovers progressive T-cell exhaustion and myeloid cell reprogramming in a CLL mouse model. [PDF]

Hemasphere
Briesch H, Coelho M, Floerchinger A, Borysovych Y, Aubert N, Medina-Gil D, Breitinger M, Zapatka M, Autenrieth SE, Seiffert M.   +9 more
europepmc   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Hematologic malignancies burden in China compared with the United States 1990-2021 and projections to 2040. [PDF]

Discov Oncol
Zheng W, Qin R, Dong H, Xiong W, Zhou X, Liu M, Guan L.   +6 more
europepmc   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

T-lymphoblastic leukemia/lymphoma: a comprehensive review of pathology, molecular features, and differential diagnosis. [PDF]

J Pathol Transl Med
Danielson D, Lagerstrom IT, Rogers M, Simon K, Aguilera NS, Auerbach A.   +5 more
europepmc   +1 more source

Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation

MedComm, Volume 7, Issue 10, October 2026.
In vivo CAR‐T cell generation directly engineers endogenous T cells using pre‐manufactured gene delivery vectors that target T cells and deliver CAR‐encoding genetic material. The resulting CAR‐T cells expand in vivo and mediate antigen‐specific cytotoxicity.
Zhenxin Bai, Ming Yi, Shengtao Hu, Dixuan Xue, Luxin Wei, Lifeng Zhang, Zhijun Dai   +6 more
wiley   +1 more source

KIT mutation and AHN-associated oncogenic profiles in systemic mastocytosis with an associated hematological neoplasm. [PDF]

Blood Adv
Navarro-Navarro P, Fernández-Giménez CM, García-Montero AC, Álvarez-Twose I, Sánchez-Muñoz L, Henriques A, Pérez-Pons A, González-Tablas M, Teodosio C, González-González M, Matarraz S, López A, Barcena P, Colado E, Esteve J, Senent ML, González-López Ó, Mollejo M, Morales-Cabeza C, Jara-Acevedo M, Orfao A.   +20 more
europepmc   +1 more source

Pneumomediastinum and Subcutaneous Emphysema After Rapid Mediastinal Mass Regression

eJHaem, Volume 7, Issue 5, October 2026.
Fahad Alsayed, Ailish Coblentz, Oussama Abla   +2 more
wiley   +1 more source

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source