Results 201 to 210 of about 388,053 (254)

Felty Syndrome–Associated Clonal Cytotoxic T‐Cell Disease With Terminal Aggressive Progression: Shared STAT3 and TET2 Mutations Across a Prolonged Disease Course

open access: yeseJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Biological overlap between Felty syndrome (FS) and clonal cytotoxic T‐cell disorders is increasingly recognized, but aggressive progression is uncommon. Methods We investigated an autopsy‐confirmed case of terminal aggressive clonal T‐cell disease that developed after a 4‐year clinical course diagnosed as FS using serial ...
Kei Saito   +11 more
wiley   +1 more source

Repeated Response to Daratumumab in Refractory MGUS‐Associated Pure Red Cell Aplasia Persisting After Allogeneic Transplantation: A Case Report

open access: yeseJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Pure red cell aplasia (PRCA) is usually managed as a disorder driven predominantly by cellular immune mechanisms, but plasma cell‐directed therapy may be relevant in selected cases associated with monoclonal gammopathy. We report a case of refractory PRCA associated with IgG‐kappa monoclonal gammopathy of undetermined significance (MGUS). A 64‐
Kyoko Yoshihara   +9 more
wiley   +1 more source

Myeloid/lymphoid neoplasm with FLT3 gene fusion: report of a case with a novel t(5;13)(q13;q12) SSBP2::FLT3 fusion. [PDF]

open access: yesJ Hematop
Cook JR   +6 more
europepmc   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

open access: yesMedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao   +5 more
wiley   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta   +2 more
wiley   +1 more source

Concurrent CML and MBL in a COPD patient: a case of collision hematologic malignancies and opportunistic infection. [PDF]

open access: yesFront Med (Lausanne)
Zhang L   +8 more
europepmc   +1 more source

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