Results 191 to 200 of about 157,947 (291)

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Notch2, a Key Player in Chronic Lymphocytic Leukemia: Mechanism, Microenvironment Interactions, and Therapeutic Implications. [PDF]

Cancers (Basel)
Miserendino R, Atene CG, Luppi M, Marasca R, Fiorcari S.   +4 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Intrathoracic manifestations of hematologic malignancies: a narrative review. [PDF]

Ann Transl Med
Bhyravabhotla K, Gaskey G, Walder JR, Balachandran DD, Cherian SV, Zafar B, Bashoura L, Sheshadri A, Faiz SA.   +8 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

CSF1R marks a subset of foetal haematopoietic multipotent progenitor cells with acute myeloid leukaemia propagation properties. [PDF]

Leukemia
Camiolo G, González Silvera D, Leah T, Schwaller J, Ottersbach K.   +4 more
europepmc   +1 more source

Lymphoid Leukemia in Remission [PDF]

, 2020
openaire   +1 more source

An Ad5‐Based COVID‐19 Vaccine Encoding SARS‐CoV‐2 Spike Glycoprotein Induces Measurable Antibody and Cytokine Responses in Mice

Biotechnology Journal, Volume 21, Issue 3, March 2026.
Graphical Abstract and Lay Summary A recombinant adenovirus type 5–based vaccine encoding the full‐length SARS‐CoV‐2 Spike glycoprotein (Ad5Spike) was evaluated for its ability to induce cellular and humoral immune responses in BALB/c mice. Immunization with Ad5Spike resulted in the generation of antigen‐specific cellular immunity, characterized by ...
Fulya Erendor, Fatih Uzer, Salih Sanlioglu   +2 more
wiley   +1 more source

Mixed phenotype acute leukemia, the dissection of an enigmatic disease in the era of novel therapies. [PDF]

Front Pediatr
Karasek M, Kubiszewska I, Sobas M.
europepmc   +1 more source