Results 41 to 50 of about 689,537 (284)

Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia

Journal of Hematology & Oncology, 2015
Targeted therapy has been the forefront of cancer treatment. Cancer immunotherapy is the most recent focus. In addition, novel immunotherapeutics targeting B cell receptor signaling (e.g., ibrutinib), T cell receptor ( e.g., CART19), and NK cells (e.g ...
Jingjing Wu, Jiaping Fu, Mingzhi Zhang, Delong Liu   +3 more
semanticscholar   +1 more source

Clonal Evolution of B-Cell Acute Lymphoblastic Leukemia with del(9)(p13p21) into Mixed Phenotype Acute Leukemia Presenting as an Isolated Testicular Relapse

Reports, 2019
Lineage switch in acute leukemias is a well-reported occurrence; however, most of these cases involve a switch from either lymphoid to myeloid or myeloid to lymphoid lineage.
Lane H. Miller, Sunita I. Park, Debra Saxe, Glen Lew, Sunil S. Raikar   +4 more
doaj   +1 more source

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia.

Blood, 2015
B-lymphocyte development in the bone marrow is controlled by the coordinated action of transcription factors creating regulatory networks ensuring activation of the B-lymphoid program and silencing of alternative cell fates.
R. Somasundaram, M. Prasad, Jonas Ungerbäck, M. Sigvardsson   +3 more
semanticscholar   +1 more source

Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKC subversion induces up-regulation of PKC II expression in B lymphocytes [PDF]

, 2015
Overwhelming evidence identifies the microenvironment as a critical factor in the development and progression of chronic lymphocytic leukemia, underlining the importance of developing suitable translational models to study the pathogenesis of the disease.
Cosimo, Emilio, Dunn, Karen, Gribben, John G., Holroyd, Ailsa, Mccaig, Alison M., McClanahan, Fabienne, Michie, Alison, Nakagawa, Rinako, Ramsay, Alan G., Tarafdar, Anuradha, Vukovic, Milica   +10 more
core   +3 more sources

Analysis of lymphocytic leukemia trends among gender, race, age, and regional groups in the U.S. between 1999-2022: a CDC-WONDER database study

Frontiers in Oncology
BackgroundLymphocytic leukemia (LL) is a prominent group of hematological cancers afflicting both children and adults of all backgrounds and demographics.
Shannon Blee, Bob Weng, Taylor Billion, Ali Bin Abdul Jabbar, Abubakar Tauseef, Mohsin Mirza   +5 more
doaj   +1 more source

Prevalence of Leukemia and Associated Factors among Patients with Abnormal Hematological Parameters in Jimma Medical Center, Southwest Ethiopia: A Cross-Sectional Study

Advances in Hematology, 2020
Introduction. Leukemia is a heterogeneous group of hematological disorder which comprise several diverse and biologically distinct subgroups. Leukemia represents the 11th and 10th most frequent cause of cancer morbidity and mortality worldwide ...
Woldeteklehaymanot Kassahun, Girum Tesfaye, Lealem Gedefaw Bimerew, Diriba Fufa, Wondimagen Adissu, Tilahun Yemane   +5 more
doaj   +1 more source

Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment.
Flávia Tobaldini Russo, Maria Cristina Martins de Almeida Macedo, Pedro Amoedo Fernandes, Larissa Yukari Okada, Lucas Augusto Monetta da Silva, Camila Menin Simões, Jamilla Neves Cavalcante, Aline de Almeida Simões, Manuella de Souza Sampaio Almeida, Maricy Almeida Viol Ferreira Lopes, Roberto Luiz da Silva   +10 more
doaj   +1 more source

CD127+ innate lymphoid cells are dysregulated in treatment naïve acute myeloid leukemia patients at diagnosis

Haematologica, 2015
Innate lymphoid cells (ILCs), defined as lineage negative (Lin−) CD127+ cells, have emerged as novel important immune effector cells, playing a critical role also in tumor immunosurveillance.[1][1]–[5][2] Recently, it was shown that the number of ILCs in
S. Trabanelli, A. Curti, Mariangela Lecciso, B. Salomé, C. Riether, A. Ochsenbein, P. Romero, C. Jandus   +7 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Flow cytometric evaluation and outcomes of pediatric acute leukemia patients

Cukurova Medical Journal, 2021
Purpose: In this study, the outcomes and flow cytometry results of childhood acute leukemia patients and their relationship with the prognosis and other clinical conditions was investigated.
İbrahim Bayram, Serhan Küpeli, Burcu Genç, Gülay Sezgin, Atila Tanyel,i, Ayşe Özkan   +5 more
doaj