Results 261 to 270 of about 346,103 (330)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment

Food Frontiers, EarlyView.
Natural small molecules through nanocarriers for cancer treatment ABSTRACT Cancer is a formidable adversary, accounting for the second highest number of fatalities worldwide. A multitude of studies have indicated that naturally sourced small‐molecule compounds, owing to their low toxicity and multi‐target capabilities, significantly aid in the fight ...
Fangting Ye, Shaojie Zheng, Shuo Shan, Jiaer Cai, Yufan Liu, Weichao Chen, Xinxin He, Chao Zhao   +7 more
wiley   +1 more source

Impact of neighborhood archetypes on overall mortality among young patients with acute leukemia in California. [PDF]

Cancer
Winestone LE, Yang J, Banerjee T, Sangaramoorthy M, Kahn J, Abrahão R, Keegan TH, Cheng I, Gomez SL, Shariff-Marco S.   +9 more
europepmc   +1 more source

Molecular response of a patient with e19a2-positive chronic myeloid leukemia to flumatinib: a case report and literature review. [PDF]

Front Med (Lausanne)
Feng Y, Wang H, Zhang L, Gong J, Liu X, Mu C, Qiao J, Meng H, Zhang Y.   +8 more
europepmc   +1 more source

Global, regional, and national burden of leukemia, 1990-2021: a systematic analysis of the global burden of disease in 2021. [PDF]

Front Med (Lausanne)
Chen J, Pang W, Deng M, Zheng R, Chen Y, Zhang Z, Tan Z, Bai Z.   +7 more
europepmc   +1 more source

Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency

Head &Neck, EarlyView.
ABSTRACT Background GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.
Brejjette Aljabi, James A. Stewart, Kirk Withrow, Carissa M. Thomas   +3 more
wiley   +1 more source

Learning the therapeutic targets of acute myeloid leukemia through multiscale human interactome network and community analysis. [PDF]

BioData Min
Sivanathan S, Hu T.
europepmc   +1 more source

Leukemia and risk of stroke: a Mendelian randomization analysis. [PDF]

BMC Neurol
Yi X, Zhu J, Zhang X, Huang N, Cheng Y.
europepmc   +1 more source

Hematopoietic cell transplants for acute leukemias. [PDF]

Haematologica
Gale RP.
europepmc   +1 more source

A common ground: an in silico assessment of the sources of intrinsic ex vivo resistance to venetoclax in acute myeloid leukemia. [PDF]

Hematol Transfus Cell Ther
Santos de Macedo BG, Albuquerque de Melo M, Pereira-Martins DA, Machado-Neto JA, Traina F.   +4 more
europepmc   +1 more source