Results 101 to 110 of about 43,548 (209)

Acute promyelocytic leukemia in a patient with chronic lymphocytic leukemia-A case report

open access: yesHematology/Oncology and Stem Cell Therapy, 2019
Chronic lymphocytic leukemia (CLL) is known to be associated rarely with myeloid malignancies such as acute myelogenous leukemia. In this article, we report an extremely rare occurrence of acute promyelocytic leukemia in a patient with CLL. A 71-year-old
Prajwal Boddu   +9 more
doaj   +1 more source

CMA‐mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination

open access: yesClinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Deubiquitinase USP9X suppresses SHH Medulloblastoma progression by facilitating SUFU ubiquitination. SHH promotes USP9X degradation through the CMA pathway. Combined inhibition of CMA and SHH pathway had a synergically therapeutic effect on SHH Medulloblastoma.
Binbin Gao   +12 more
wiley   +1 more source

Central Nervous System Double Relapse of Acute Promyelocytic Leukemia and Acute Myelomonocytic Leukemia

open access: yesCase Reports in Hematology, 2019
Relapse of acute promyelocytic leukemia (APL) and non-M3-acute myeloid leukemia in the central nervous system (CNS) are rare events. Here, we describe a case of simultaneous relapses of APL and acute myelomonocytic leukemia on the CNS of a patient after ...
Laura M. Stanko   +3 more
doaj   +1 more source

FORMULATION OF ORAL COMPOSITIONS COMPRISING ARSENIC TRIOXIDE AND METHODS OF USE THEREOF [PDF]

open access: yes, 2005
The present invention provides an oral formulation of arsenic trioxide (As2O3) for the treatment of a variety of hematological malignancies, including acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

core  

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

open access: yesHemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito   +6 more
wiley   +1 more source

Acute promyelocytic leukemia: the study of t(15;17) translocation by fluorescent in situ hybridization, reverse transcriptase-polymerase chain reaction and cytogenetic techniques [PDF]

open access: yes, 2001
Acute promyelocytic leukemia (AML M3) is a well-defined subtype of leukemia with specific and peculiar characteristics. Immediate identification of t(15;17) or the PML/RARA gene rearrangement is fundamental for treatment.
Antunes, S.v.   +5 more
core   +1 more source

Discordant Vitamin B12 Results in an IgA Nephropathy Patient

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
ABSTRACT Background Discordant Vitamin B12 results can result from immunoassay interferences, potentially leading to unnecessary diagnostic procedures and misdiagnoses if not properly recognized. Case Presentation A 76‐year‐old male with a history of IgA nephropathy, hypertension, and other comorbidities presented with unexpectedly elevated total ...
Oytun Portakal   +3 more
wiley   +1 more source

Acute Promyelocytic Leukemia Complicated by Deep Venous Thrombosis, Pulmonary Thromboembolism, and Hematemesis

open access: yesIndian Journal of Clinical Cardiology
Acute promyelocytic leukemia (APML) is a myeloid leukemia classified as M3-AML. It is known for its bleeding diathesis, which is predominantly driven by disseminated intravascular coagulation and primary hyperfibrinolysis.
Sudipta Mondal, Saurav Banerjee
doaj   +1 more source

Allogeneic stem cell transplantation for advanced acute promyelocytic leukemia in the ATRA and ATO era

open access: yesHaematologica, 2012
The role of allogeneic stem cell transplant in advanced acute promyelocytic leukemia patients who received standard first- and second-line therapy is still unknown.
Safaa M. Ramadan   +10 more
doaj   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

open access: yesMedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng   +8 more
wiley   +1 more source

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