Results 121 to 130 of about 1,571,497 (188)

Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy

Cancer Medicine, Volume 15, Issue 9, September 2026.
Cancer stem cell quiescence is a regulated, reversible survival mechanism, preserving stemness and promoting therapy resistance through intrinsic programs and niche signals. Targeting these pathways holds promise for eradicating quiescent CSCs and preventing recurrence.
Yasin Ahmadi, Trefa M. Abdullah, Sakhavat Abolhasani, Amin Jalizi   +3 more
wiley   +1 more source

Synthesis, Characterization, In Vitro and In Silico Investigation of Azo‐Based Co(III), Zn(II), and Pd(II) Complexes Against Human Leukemia

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A novel azo ligand (IDB) and its Co(III), Zn(II), and Pd(II) complexes were synthesized and characterized. The Pd(II) complex demonstrated potent activity against HL‐60 leukemia cells, modulated oxidative stress markers (MDA, CAT), and showed strong binding affinity (−6.6367 kcal/mol) to the Aurora kinase enzyme in molecular docking studies.
Yareeb J. Sahar, Abbas F. Yasir, Hussein A. K. Kyhoiesh   +2 more
wiley   +1 more source

Trisomy 21 in Acute Promyelocytic Leukemia

, 1987
We present a case of a 64-year-old male, diagnosed to have acute promyelocytic leukemia with trisomy 21. He came to the hospital with bleeding secondary to disseminated intravascular coagulation.
Usha Singal, Fred Koppitch, Ila Shah-Reddy   +2 more
core   +1 more source

Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape Study

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Nucleoporin 98 rearrangements (NUP98re) occur in a wide range of hematologic malignancies including acute leukemias with a variety of fusion partners. NUP98re is associated with adverse prognosis, especially in children. We aimed to better understand the genomics of acute leukemias with NUP98re including fusion partners and co‐occurring ...
Osama Batayneh, Natalie Danziger, Mahmoudreza Moein, Nour S. Naji, Dean Pavlick, Jeffrey S. Ross, Chelsea Marcus, Caleb Ho, Teresa Gentile, Zheng Zhou, Lincoln W. Pasquina   +10 more
wiley   +1 more source

All‐Trans Retinoic Acid Promotes Endometrial Regeneration and Angiogenesis Associated With Wnt/β‐Catenin Signaling in a Mouse Model of Intrauterine Adhesion

iNew Medicine, Volume 2, Issue 3, September 2026.
ATRA promotes endometrial regeneration, angiogenesis, and uterine receptivity in intrauterine adhesion, at least in part through activation of Wnt/β‐catenin signaling. ABSTRACT Objective To investigate the therapeutic effects of all‐trans retinoic acid (ATRA) on endometrial repair and the underlying mechanisms.
Ting Luo, Ting Liao, Yunxia Cao, Zhaolian Wei   +3 more
wiley   +1 more source

METTL7A‐Dependent m6A Methylation Orchestrates CXCR4hi Neutrophil Pathogenicity and NETosis in Skin Inflammation

MedComm, Volume 7, Issue 9, September 2026.
In psoriasis, METTL7A is upregulated in aged CXCR4hi neutrophils, where it stabilizes PLSCR1 mRNA via m6A modification to enhance reactive oxygen species (ROS) production and neutrophil extracellular trap (NET) formation, thereby exacerbating disease severity.
Wanting Liu, Jinkai Liang, Huiyi Quan, Xuan Liu, Kang Li, Xin Tang, Jiaqi Wang, Yunfeng Gu, Yaxing Bai, Ke Xue, Zhiguo Li, Xiaolei Su, Erle Dang, Jiaoling Chen, Gang Wang, Shuai Shao   +15 more
wiley   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Isocitrate Dehydrogenase (IDH) Mutations in Hematological Malignancies: Epidemiology, Mechanisms, and Therapeutic Strategies

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
IDH mutation is an important event in hematological malignancies. This review systematically integrates the basic mechanism of IDH mutations and combines it with the clinical translation of related research progress. It also discusses the application strategies of IDH inhibitors and feasible research directions, with the aim of providing a theoretical ...
Jinkun Xu, Haiying Bai, Lijuan Hu
wiley   +1 more source

Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance

Aging Cell, Volume 25, Issue 9, September 2026.
Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative mode of telomere replication. ABSTRACT Cell division inevitably shortens telomeric DNA owing to the end‐replication problem.
Jie Wang, Yuehui Su, Chao Chen, Yueying Li, Jiajia Han, Liping Du, Liyun Zheng, Ya‐Long Dang, Ying Peng   +8 more
wiley   +1 more source

Investigations of FLT3 internal tandem duplications in patients with acute myeloid leukaemia. [PDF]

, 2006
In acute myeloid leukaemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated an internal tandem duplication (ITD) in the FLT3 gene may adversely
Kottaridis, P.D., Kottaridis, Panagiotis
core