Results 111 to 120 of about 1,571,497 (188)

The Overture of DIC: An APL Case from Community to Cure [PDF]

Documenta Haematologica
Introduction: Acute promyelocytic leukemia (APL; M3) is a distinct subtype of acute myeloid leukemia characterized by fusion of the promyelocytic leukemia (PML) gene with retinoic acid receptor alpha (RARA), most often resulting from the t(15;17)(q24;q21)
Nasim SALIMIAGHDAM, Vivian Arguello GUERRA, Kristina ZARKUA   +2 more
doaj   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, Volume 13, Issue 54, 28 September 2026.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India

Indian Journal of Medical and Paediatric Oncology
Introduction Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia with specific molecular pathogenesis, clinical features, and treatment. It is cytogenetically characterized by translocation t (15;17) (q24;q21).
Shweta Gondha, Prerna Walia, Beena Brahmbhatt, Jayendrakumar Patel, Toral Mandalia, Disha Jethva   +5 more
doaj   +1 more source

Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA

American Journal of Hematology, Volume 101, Issue 9, Page 2246-2257, September 2026.
ABSTRACT Frameshift mutations in exon 12 of nucleophosmin 1 (NPM1 mut) are among the most common mutations in acute myeloid leukemia (AML) and have historically been considered favorable‐risk in the absence of FLT3‐ITD. In the European LeukemiaNet (ELN) 2024 risk‐classification for patients treated with hypomethylating agents plus venetoclax (HMA + VEN)
Fieke W. Hoff, Joshua F. Zeidner, Geeta Torlapati, Deedra Nicolet, Krzysztof Mrózek, Ying Huang, Alexander Li, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Maria R. Baer, Vu H. Duong, William G. Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Rebecca L. Olin, Catherine C. Smith, Gary J. Schiller, Emily K. Curran, Onyee Chan, Christine McMahon, Michael Hochman, Kieran Sahasrabudhe, Charles Foucar, Jesus Gonzalez‐Lugo, Brittany Knick Ragon, Shivani V. Handa, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja G. Marcus, Leonard Rosenberg, Brian J. Druker, Ross L. Levine, Amy Burd, Ashley O. Yocum, Uma M. Borate, Alice S. Mims, Ann‐Katrin Eisfeld, John C. Byrd, Yazan F. Madanat   +44 more
wiley   +1 more source

Undifferentiated granulocytic sarcoma: a case with epidural onset preceding acute promyelocytic leukemia

Haematologica, 1995
This study reports a case of granulocytic sarcoma that developed in the epidural zone 25 days before clinical evidence of an acute promyelocytic leukemia.
A Tosi, A De Paoli, S Fava, M Luoni, M Sironi, A Tocci, A Assi, E Cassi   +7 more
doaj  

Diagnosis and management of acute promyelocytic leukemia: Brazilian consensus guidelines 2024 on behalf of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy

Hematology, Transfusion and Cell Therapy
Improvements in clinical assessment have occurred since the last published recommendations on the diagnosis and treatment of acute promyelocytic leukemia in 2013.
Lorena Lobo de Figueiredo-Pontes, Luiz Fernando Bazzo Catto, Maria de Lourdes Lopes Ferrari Chauffaille, Katia Borgia Barbosa Pagnano, Maria Isabel Ayrosa Madeira, Elenaide Coutinho Nunes, Nelson Hamerschlak, Marcela Cavalcante de Andrade Silva, Thiago Xavier Carneiro, Teresa Cristina Bortolheiro, Tiago Thalles de Freitas, Rosane Isabel Bittencourt, Evandro Maranhão Fagundes, Eduardo Magalhães Rego   +13 more
doaj   +1 more source

The factors affecting early death in newly diagnosed APL patients

Open Medicine, 2019
In the past, acute promyelocytic leukemia (APL) was considered as one of the most rapidly lethal form of acute myeloid leukemia (AML). The objective of this study was to assess clinical parameters affecting early death (ED) in patients with APL.
Ciftciler Rafiye, Haznedaroglu Ibrahim Celalettin, Aksu Salih, Ozcebe Osman, Sayınalp Nilgun, Malkan Umit Yavuz, Buyukasık Yahya   +6 more
doaj   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

EfficientNet‐B0–Based Screening of WBC‐Diff Scattergram Images for Hematological Abnormalities

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT White blood cell differential (WBC‐Diff) scattergrams are used to screen for hematological abnormalities in potential hematopoietic malignancies and abnormal conditions. However, these potential indications can be easily missed. We applied deep learning models to develop a new and rapid workflow by learning the characteristics of WBC‐Diff ...
Mingzhu Long, Xuan Luo, Lixia Zhang, Te Chen, Haixia Wang   +4 more
wiley   +1 more source

Prognostic Significance of Secondary‐Type Mutations in NPM1‐Mutated Acute Myeloid Leukemia

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML), and NPM1‐mutated AML is generally associated with a favorable prognosis. However, substantial prognostic heterogeneity exists within this population. The prognostic significance of secondary‐type mutations (STMs) in NPM1‐mutated AML remains controversial.
Kun Yang, Hongmei Luo, Bing Xiang, Yang Dai, Yuping Gong, Jie Huang, Jianjun Li, Yongqian Jia, Yong Guo, Yuhuan Zheng, Hongbing Ma   +10 more
wiley   +1 more source