Results 111 to 120 of about 43,548 (209)

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

Acute lower limb ischemia revealing hypo granular acute promyelocytic leukemia

Leukemia Research Reports
Introduction: Acute promyelocytic leukemia (AML-M3), classified as acute Myeloid leukemia with PML RARA according to the 5th edition of the World Health Organization classification of haematolymphoid tumors 2022 [1], is marked by abnormal promyelocyte ...
Sabrina Belmahi, Zainab Kajeiou, Loubna Yacoubi, Noussaiba Azzi, Mounia Slaoui, Abdelilah Berhili, Mohammed Bensalah, Rachid Seddik   +7 more
doaj   +1 more source

Regulation of 92-kD gelatinase release in HL-60 leukemia cells [PDF]

, 1994
Matrix metalloproteinase 9 (MMP-9), also known as 92-kD type IV collagenase/gelatinase, is believed to play a critical role in tumor invasion and metastasis. Here, we report that MMP-9 was constitutively released from the human promyelocytic cell line HL-
Kolb, H., Petrides, P. E., Ries, Christian   +2 more
core  

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

Diagnosis and management of acute promyelocytic leukemia: Brazilian consensus guidelines 2024 on behalf of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy

Hematology, Transfusion and Cell Therapy
Improvements in clinical assessment have occurred since the last published recommendations on the diagnosis and treatment of acute promyelocytic leukemia in 2013.
Lorena Lobo de Figueiredo-Pontes, Luiz Fernando Bazzo Catto, Maria de Lourdes Lopes Ferrari Chauffaille, Katia Borgia Barbosa Pagnano, Maria Isabel Ayrosa Madeira, Elenaide Coutinho Nunes, Nelson Hamerschlak, Marcela Cavalcante de Andrade Silva, Thiago Xavier Carneiro, Teresa Cristina Bortolheiro, Tiago Thalles de Freitas, Rosane Isabel Bittencourt, Evandro Maranhão Fagundes, Eduardo Magalhães Rego   +13 more
doaj   +1 more source

The factors affecting early death in newly diagnosed APL patients

Open Medicine, 2019
In the past, acute promyelocytic leukemia (APL) was considered as one of the most rapidly lethal form of acute myeloid leukemia (AML). The objective of this study was to assess clinical parameters affecting early death (ED) in patients with APL.
Ciftciler Rafiye, Haznedaroglu Ibrahim Celalettin, Aksu Salih, Ozcebe Osman, Sayınalp Nilgun, Malkan Umit Yavuz, Buyukasık Yahya   +6 more
doaj   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source

Pattern of Expression of PML-RARα Transcripts in Acute Promyelocytic Leukemia Patients and Its Correlation with Overall Survival: A Retrospective Study from Western India

Indian Journal of Medical and Paediatric Oncology
Introduction Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia with specific molecular pathogenesis, clinical features, and treatment. It is cytogenetically characterized by translocation t (15;17) (q24;q21).
Shweta Gondha, Prerna Walia, Beena Brahmbhatt, Jayendrakumar Patel, Toral Mandalia, Disha Jethva   +5 more
doaj   +1 more source

Acute promyelocytic leukemia.

The Western journal of medicine, 1987
Acute promyelocytic leukemia (APL) is a subtype of acute myelogenous leukemia frequently associated with disseminated intravascular coagulation (DIC). Data on 11 patients with APL treated at our institution were analyzed and compared with those of 147 published cases.
E C, Kingsley, B G, Durie, H S, Garewal
openaire   +1 more source

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues

, 2013
We model a general, hierarchically organized tissue by a multi compartment approach, allowing any number of mutations within a cell. We derive closed solutions for the deterministic clonal dynamics and the reproductive capacity of single clones.
Dingli, D., Traulsen, A., Werner, B.
core   +1 more source