Results 51 to 60 of about 43,548 (209)
Acute promyelocytic leukemia, hypogranular variant: a rare presentation
Clinics and Practice, 2011 Early diagnosis of acute promyelocytic leukemia (APL) is essential because of its associated life threatening coagulopathy and unique response to all trans-retinoic acid (ATRA) therapy.
Kafil Akhtar +2 more
doaj +1 more source
Therapeutic Advances in Hematology, 2021 Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene.
Xiaoyan Han +7 more
doaj +1 more source
Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3
Stem Cell Research, 2022 Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α ...
Ji-Hea Kim +4 more
doaj +1 more source
Expression profiling of snoRNAs in normal hematopoiesis and AML [PDF]
, 2018 Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in ...
Helton, Nichole +6 more
core +2 more sources
RORγt‐APCs: The New Masters of Oral Tolerance
Barrier Immunity, EarlyView.ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley +1 more source
The Tribble with APL: a new road to therapy [PDF]
, 2017 The t(15;17) translocation generates a PML-RARα fusion protein causative for acute promyelocytic leukemia (APL). Li et al. now identify the pseudokinase stress protein TRIB3 as an important factor in APL disease progression and therapy resistance ...
Carmody, Ruaidhri, Keeshan, Karen
core +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Example of leukocyte classification results by FCM. The 16 cell populations are displayed in different colors according to the set gate logic. ABSTRACT Objective Assess the application value of flow cytometry (FCM) for peripheral blood leukocyte (PBL) classification in acute leukemia (AL) screening and monitoring.
Penghua Yan +4 more
wiley +1 more source
PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice
Haematologica, 2013 Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. To identify co-operating pathways to leukemogenesis, we crossed MRP8-PML/RARA transgenic mice with BXH-2 mice which harbor an ...
Nader Omidvar +9 more
doaj +1 more source
Saudi Journal for Health Sciences, 2023 Acute promyelocytic leukemia (APML) is a rare subtype of acute myeloid leukemia characterized by the predominance of atypical promyelocytes. Acute perforating appendicitis with atypical promyelocytic infiltration of the appendix is exceptionally rare ...
Majed Abdul Basit Momin +5 more
doaj +1 more source
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation [PDF]
, 2003 We utilized a mouse model of acute promyelocytic leukemia (APL) to investigate how aberrant activation of cytokine signaling pathways interacts with chimeric transcription factors to generate acute myeloid leukemia.
Phan, Vernon T. +7 more
core +1 more source