Results 61 to 70 of about 21,951 (195)

All-trans-retinoic-acid and arsenic trioxide induced remission in promyelocytic blast crisis

Leukemia Research Reports, 2018
A 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-
Teresa A. Colvin, Pankit Vachhani, Sheila Sait, Vishala Neppalli, Eunice S. Wang   +4 more
doaj   +1 more source

Clinical, Genetic, and Pathologic Variability in Myelodysplastic Syndromes and Precursor Conditions Across Race, Ethnicity, and Sex

American Journal of Hematology, Volume 101, Issue 6, Page 1407-1420, June 2026.
ABSTRACT The epidemiology of myelodysplastic syndromes/neoplasms (MDS) is challenging to define due to inconsistent reporting, complex diagnostic procedures, and evolving diagnostic criteria. Using the National MDS Natural History Study—a prospective cohort with centrally adjudicated histopathology and genetic variant review—we characterized the ...
Nancy Gillis, Christelle Colin‐Leitzinger, Yi‐Han Tang, Michael Otterstatter, Seth Sherman, Ling Zhang, Lynn C. Moscinski, Mary Ellen Walker, Jeffrey S. Painter, Gregory A. Abel, Tareq Al Baghdadi, H. Joachim Deeg, James M. Foran, Steven D. Gore, Alexandra M. Harrington, Steven H. Kroft, Jane Jijun Liu, Wael Saber, Shamsuddin Virani, Rafael Bejar, R. Coleman Lindsley, Eric Padron, Matthew J. Walter, Rami Komrokji, Amy E. DeZern, Mikkael A. Sekeres   +25 more
wiley   +1 more source

Promyelocytic sarcoma of the right humerus: an unusual clinical presentation with unique diagnostic and treatment considerations

Clinical Case Reports, 2017
Key Clinical Message Promyelocytic leukemia is a known medical emergency and requires rapid diagnosis and expedient therapy with differentiating agents.
Sameer Sawhney, Noa G. Holtzman, Derik L. Davis, Hannah Kaizer, Victoria Giffi, Ashkan Emadi, Rima Koka   +6 more
doaj   +1 more source

Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation

Hematology Reports
Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the ...
Sara Frazzetto, Lara Gullo, Gabriele Sapuppo, Manlio Fazio, Cristina Lo Faro, Giuliana Giunta, Ignazio Caravotta, Elisa Mauro, Marina Silvia Parisi, Anna Maria Triolo, Nunziatina Laura Parrinello, Maria Letizia Consoli, Loredana També, Daniela Cambria, Sara Marino, Grazia Scuderi, Francesco Di Raimondo   +16 more
doaj   +1 more source

From Leukemia to Solid Tumors, Successful Multidisciplinary Management of Three Distinct Primary Cancers in a Single Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT A 41‐year‐old man developed three distinct primary malignancies—acute myeloid leukemia, male breast cancer, and metastatic colorectal cancer—within 7 years. This rare case highlights the evolving challenge of multiple primary cancers and demonstrates how coordinated multidisciplinary care can preserve curative intent despite successive life ...
Abolfazl Khalafi‐Nezhad, Nazanin Alemzadeh, Mohammad Hossein Anbardar, Zahra Ghanbarinasab   +3 more
wiley   +1 more source

Qingdainone, a novel bioactive compound in Realgar‒Indigo naturalis, induced apoptosis and differentiation in ATRA‐sensitive and ‐resistant acute promyelocytic leukaemia cells

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Network pharmacology identified Qingdainone as a key bioactive compound in RIF. 2. Molecular docking revealed strong binding affinities of Qingdainone to targets such as CCND1, CDK1, CDK4, CASP3 and CASP7. 3. Qingdainone interfered proliferation and apoptosis, and promoted differentiation, of ATRA‐sensitive and ‐resistant APL cells, such that ...
Pengcheng Xu, Yang Ou, Xin Tan, Lili Ji, Yanxia Zhan, Pu Chen, Hao Chen, Yunfeng Cheng   +7 more
wiley   +1 more source

NAT10‐mediated N4‐acetylcytidine modification drives RNA splicing of PML to alleviate adipose‐derived stem cell senescence and promote diabetic wound healing

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
N‐acetyltransferase 10 (NAT10) catalyses N4‐acetylcytidine (ac4C) modification of PML pre‐mRNA, shifting splicing from the senescence‐promoting PML‐FL to the senescence‐inhibiting PML‐S isoform via SRSF1. This rejuvenates adipose‐derived stem cells (ADSCs) by reducing senescence markers and senescence‐associated secretory phenotype (SASP), thereby ...
Wuhan Wei, Chanyuan Jiang, Dong Zhu, Xuefeng Han, Xuan Ma, Xinyu Jia, Jiaqi Ling, Rui Zhang, Facheng Li, Ningbei Yin   +9 more
wiley   +1 more source

Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Using cyclic multiplex microscopy in an IL‐33‐driven type 2 inflammation model, we validated a spatial workflow mapping rare lung ILCs. High‐dimensional analysis revealed a conserved peri‐lymphatic niche at early time points of inflammation where ILC2s and myeloid cells co‐localize with LYVE1+ vessels, highlighting a structured immunological ...
Sandy Kroh, Anna Pascual‐Reguant, Artür Manukyan, Ralf Uecker, Robert Günther, Lars Philipsen, Ralf Koehler, Peggy Mex, Markus Landthaler, Raluca A. Niesner, Anja E. Hauser   +10 more
wiley   +1 more source

Acute promyelocytic leukemia presenting with features of metastatic osseous disease

Leukemia Research Reports, 2018
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid ...
Carmen Winters, Andy I. Chen, Stephen Moore, Elie Traer, Jennifer Dunlap   +4 more
doaj   +1 more source

Pharmacological and Phytochemical Insights Into Ficus benghalensis (Indian Banyan): Anti‐Inflammatory, Antioxidant, and Anticancer Potentials

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The aim of this review is to critically evaluate the therapeutic potential of Ficus benghalensis L. by integrating ethnomedicinal knowledge with contemporary scientific evidence. The objectives are to summarize its phytochemical profile, analyze antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and anticancer activities, elucidate underlying
Zainab Ali, Farhang Hameed Awlqadr, Uswa Ali, Iffat Ullah, Muhammad Tayyab Arshad, Abdul Rauf, Humaira Parveen, Sayeed Mukhtar, Uzma Faridi, Md. Sakhawot Hossain   +9 more
wiley   +1 more source