Results 51 to 60 of about 1,571,497 (188)
Acute promyelocytic leukemia, hypogranular variant: a rare presentation
Clinics and Practice, 2011 Early diagnosis of acute promyelocytic leukemia (APL) is essential because of its associated life threatening coagulopathy and unique response to all trans-retinoic acid (ATRA) therapy.
Kafil Akhtar +2 more
doaj +1 more source
Relapse as hypogranular morphologic subtype in classic acute promyelocytic leukemia [PDF]
Romanian Journal of Medical Practice, 2016 We present the case of patient who had morphologically different cells (atypical promyelocytic) when disease relapse, which led to the establishment of two diagnoses. The final diagnosis was of acute promyelocytic leukemia – hipogranular form.
Tatiana Cristina ENACHE +3 more
doaj +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Mutations in FLT3 are present in approximately 30% of patients with AML. The addition of midostaurin (MIDO) to intensive chemotherapy (IC) became standard of care following the RATIFY trial, but comprehensive real‐world data spanning the full adult age spectrum and including both FLT3‐ITD and FLT3‐TKD mutations remain limited.
Mónica Alejandra Romero Riquelme +49 more
wiley +1 more source
Análise dos polimorfismos dos transcritos da translocação T(15;17)(Q22;Q21) na leucemia promielocítica aguda [PDF]
, 2013 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.As leucemias agudas (LAs) constituem um grupo de neoplasias malignas caracterizado pela proliferação descontrolada de células hematopoiéticas na medula óssea
Silveira, Amanda da Silva
core
Regulation of 92-kD gelatinase release in HL-60 leukemia cells [PDF]
, 1994 Matrix metalloproteinase 9 (MMP-9), also known as 92-kD type IV collagenase/gelatinase, is believed to play a critical role in tumor invasion and metastasis. Here, we report that MMP-9 was constitutively released from the human promyelocytic cell line HL-
Petrides, P. E. +2 more
core +1 more source
FLT3 Length Mutations as Marker for Follow-Up Studies in Acute Myeloid Leukaemia [PDF]
, 2004 Length mutations within the FLT3 gene (FLT3-LM) can be found in 23% of acute myeloid leukaemia (AML) and thus are the most frequent mutations in AML. FLT3-LM are highly correlated with AML with normal karyotype and other cytogenetic aberrations of the ...
Kern, Wolfgang +4 more
core +1 more source
Therapeutic Advances in Hematology, 2021 Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene.
Xiaoyan Han +7 more
doaj +1 more source
MANAGEMENT OF ACUTE PROMYELOCYTIC LEUKEMIA IN THE ELDERLY
Mediterranean Journal of Hematology and Infectious Diseases, 2013 Unlike other forms of AML, APL is less frequently diagnosed in the elderly and has a relatively favourable outcome. Elderly patients with APL seem at least as responsive to therapy as do younger patients, but rates of response and survival are lower in this age setting owing to a higher incidence of early deaths and deaths in remission when ...
Lo-Coco F., Latagliata R., Breccia M.
openaire +4 more sources
Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia [PDF]
, 2020 Simple SummaryIn solid tumors, the altered expression of embryonic genes such as the SLIT-ROBO family has been associated with poor prognosis, while little is known about their role in acute myeloid leukemia (AML).
Jan Jacob Schuringa +62 more
core +2 more sources
Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3
Stem Cell Research, 2022 Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α ...
Ji-Hea Kim +4 more
doaj +1 more source