Results 81 to 90 of about 43,548 (209)

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Management of elderly patients with acute promyelocytic leukemia: progress and problems [PDF]

, 2013
Despite substantial progress in the management and outcome of acute promyelocytic leukemia (APL) during the last decades, older age remains a prominent negative prognostic factor.
Eva Lengfelder, Florian Nolte, Wolf-Karsten Hofmann   +2 more
core   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

Differentiation syndrome in patients with acute promyelocytic leukemia treated with all- trans retinoic acid and anthracycline chemotherapy: Characteristics, outcome, and prognostic factors [PDF]

, 2009
Differentiation syndrome (DS) can be a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy with all- trans retinoic acid (ATRA). Detailed knowl- edge about DS has remained limited.
Adès, Angel León, Avvisati, Bennett, Bennett, Bob Lowenberg, Chelo Rayón, Cheson, Concha Rivas, Cortes, Cox, Cox, Cunha De Santis, De Botton, De Botton, De la Serna, Di Noto, Dixon, Edo Vellenga, Elena Amutio, Falanga, Fenaux, Frankel, Guillermo Debén, Gustavo Milone, Javier de la Serna, Joaquín Díaz-Mediavilla, Jordi Esteve, Jose D. González, Juan M. Bergua, Kanamaru, Kaplan, Ko, Larson, Lee, Lengfelder, Mandelli, Mar Tormo, Marcos González, Miguel A. Sanz, Pau Montesinos, Ricardo Parody, Salut Brunet, Sanz, Sanz, Sanz, Sanz, Silvia Negri, Tallman, Tallman, Vahdat, Wiley, Wu, Yanada   +53 more
core   +4 more sources

Twenty Years of Therapeutic Leukocytapheresis in Newly Diagnosed Acute Myeloid Leukemia: Insights From A Single Center

Journal of Clinical Apheresis, Volume 41, Issue 2, April 2026.
ABSTRACT Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy, and 5%–20% of newly diagnosed patients present with hyperleukocytosis (HL). HL, most often defined as WBC > 100 000/μL, is a hematologic emergency associated with severe complications, early mortality, and poor prognosis, requiring immediate intervention.
Vojtech Latal, Ivana Skoumalova, Miroslava Palova, Tomas Szotkowski, Martin Cernan, Jana Navratilova, Helena Urbankova, Zuzana Pikalova, Ludek Raida, Edgar Faber, Tomas Papajik   +10 more
wiley   +1 more source

All-trans-retinoic-acid and arsenic trioxide induced remission in promyelocytic blast crisis

Leukemia Research Reports, 2018
A 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-
Teresa A. Colvin, Pankit Vachhani, Sheila Sait, Vishala Neppalli, Eunice S. Wang   +4 more
doaj   +1 more source

HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons. [PDF]

, 2012
Major human pathologies are caused by nuclear replicative viruses establishing life-long latent infection in their host. During latency the genomes of these viruses are intimately interacting with the cell nucleus environment.
Catez, Frédéric, Gross, Sylvain, Held, Kathrin, Labetoulle, Marc, Lomonte, Patrick, Picard, Christel, Rousseau, Antoine, Sawtell, Nancy, Theil, Diethilde   +8 more
core   +5 more sources

Promyelocytic sarcoma of the right humerus: an unusual clinical presentation with unique diagnostic and treatment considerations

Clinical Case Reports, 2017
Key Clinical Message Promyelocytic leukemia is a known medical emergency and requires rapid diagnosis and expedient therapy with differentiating agents.
Sameer Sawhney, Noa G. Holtzman, Derik L. Davis, Hannah Kaizer, Victoria Giffi, Ashkan Emadi, Rima Koka   +6 more
doaj   +1 more source

Hyperleukocytosis and Access to Minimal Residual Disease Testing Impact Outcomes in Children With Newly Diagnosed Acute Myeloid Leukemia in Thailand

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background The survival outcomes among children with acute myeloid leukemia (AML) in low‐ and middle‐income countries are still poor despite adopting modern treatment regimens from developed countries. The study aimed to identify additional potential determinant factors for relapse and death among children with AML in Thailand. Methods In all,
Piya Rujkijyanont, Supak Ukritchon, Angkana Winaichatsak, Pitchayanan Kuwatjanakul, Thirachit Chotsampancharoen, Piti Techavichit, Su‐on Chainansamit, Lalita Sathitsamitphong, Kittima Kanchanakamhaeng, Usanarat Anurathapan, Napat Laoaroon, Chonthida Wangkittikal, Chalinee Monsereenusorn, Watinee Sanpote, Nattaporntira Phalakornkul, Pariwan Sripattanatadasakul, Daranee Isaranimitkul, Pokpong Na Songkhla, Phakatip Sinlapamongkolkul, Jassada Buaboonnam, Samart Pakakasama   +20 more
wiley   +1 more source

Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation

Hematology Reports
Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the ...
Sara Frazzetto, Lara Gullo, Gabriele Sapuppo, Manlio Fazio, Cristina Lo Faro, Giuliana Giunta, Ignazio Caravotta, Elisa Mauro, Marina Silvia Parisi, Anna Maria Triolo, Nunziatina Laura Parrinello, Maria Letizia Consoli, Loredana També, Daniela Cambria, Sara Marino, Grazia Scuderi, Francesco Di Raimondo   +16 more
doaj   +1 more source