Results 191 to 200 of about 1,360,875 (361)

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

open access: yesAdvanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu   +5 more
wiley   +1 more source

Myeloid neoplasms with MYC-positive double minutes: towards recognition as a distinct entity

open access: yesBlood Cancer Journal
Isolde Summerer   +12 more
doaj   +1 more source

P763: VENETOCLAX WITH AZACITIDINE IN RELAPSE/REFRACTORY HIGHER RISK MYELODYSPLASTIC SYNDROME: UPDATED PHASE 1 RESULTS

open access: yesHemaSphere, 2022
S. P. Desikan   +8 more
doaj   +1 more source

A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition. [PDF]

open access: yesRSC Chem Biol
Barta PA   +9 more
europepmc   +1 more source

Polycythemia Vera Terminating with Myeloblastic Leukemia [PDF]

open access: bronze, 1954
Marjorie J. Williams, Julius L. Mendel
openalex   +1 more source

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

open access: yesAdvanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin   +7 more
wiley   +1 more source

Two ways to complex karyotype in MDS—the role of del(5q) and TP53

open access: yesBlood Cancer Journal
Sandra Huber   +7 more
doaj   +1 more source

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