Results 41 to 50 of about 1,123,126 (369)

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow

Haematologica, 2012
We investigated 15,542 patients with suspected BCR-ABL1- negative myeloproliferative or myelodysplastic/myeloproliferative neoplasm (including 359 chronic myelomonocytic leukemia) by a molecular marker set.
Susanne Schnittger, Ulrike Bacher, Christiane Eder, Frank Dicker, Tamara Alpermann, Vera Grossmann, Alexander Kohlmann, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach   +9 more
doaj   +1 more source

FANCA: In-Silico deleterious mutation analysis for early prediction of leukemia [PDF]

arXiv, 2021
As a novel biomarker from the Fanconi anemia complementation group (FANC) family, FANCA is antigens to Leukemia cancer. The overexpression of FANCA has predicted the second most common cancer in the world that is responsible for cancer-related deaths.
arxiv  

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Chen, Xiao, Guenther, Wolfgang, Kolb, Hans-Jochem, Ledderose, Georg, Roskrow, Marie, Schleuning, Michael, Schmid, Christoph, Weber, Martin, Woiciechowski, Anja   +8 more
core   +1 more source

DNMT3A in Leukemia [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
DNA methylation is an epigenetic process involved in development, aging, and cancer. Although the advent of new molecular techniques has enhanced our knowledge of how DNA methylation alters chromatin and subsequently affects gene expression, a direct link between epigenetic marks and tumorigenesis has not been established.
Michael C. Gundry, Michael C. Gundry, Lorenzo Brunetti, Margaret A. Goodell   +3 more
openaire   +3 more sources

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Automated Detection of Acute Promyelocytic Leukemia in Blood Films and Bone Marrow Aspirates with Annotation-free Deep Learning [PDF]

arXiv, 2022
While optical microscopy inspection of blood films and bone marrow aspirates by a hematologist is a crucial step in establishing diagnosis of acute leukemia, especially in low-resource settings where other diagnostic modalities might not be available, the task remains time-consuming and prone to human inconsistencies.
arxiv  

Road traffic pollution and childhood leukemia: a nationwide case-control study in Italy [PDF]

, 2016
Background The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes.
Alberto Salvan, Alessandra Benvenuti, Alessandra Greco Veneto, Alessandra Ranucci, Alessandra Ranucci, Alessandro Polichetti, Alessandro Pulsoni, Andrea Farioli, Andrea Pession, Carmelo Rizzari, Chiara Badaloni, Claudia Galassi, Corrado Magnani, Corrado Magnani, Cristina Nuccetelli, Daniela Ferrante, Daniela Ferrante, Daniele Monetti, Domenico Franco Merlo, Domenico Franco Merlo, Egidio Celentano, Egidio Celentano, Erni Guarino, Francesco Bochicchio, Francesco Forastiere, Francesco Forastiere, Franco Locatelli, Franco Pannelli, Gabriella Bernini, Gian Luca DeSalvo, Gigliola de Nichilo, Gino Schilirò, Giorgio Assennato, Giorgio Assennato, Giulia Cesaroni, Giuseppe Masera, Giuseppe Sampietro, Lia Lidia Luzzatto, Liliana Minelli, Liliana Minelli, Lorenzo Gafà, Lucia Miligi, Lucia Miligi, Luigi Bisanti, Luigi Bisanti, Manuela Chiavarini, Maria Valeria Torregrossa, Maria Valeria Torregrossa, Marina Cuttini, Marina Cuttini, Maurizio Aricò, Paola Michelozzi, Paola Michelozzi, Paola Mosciatti, Paola Mosciatti, Paola Zambon, Paola Zambon, Pia Massaglia, Pierfranco Biddau, Pierluigi Cocco, Pierluigi Cocco, Riccardo Haupt, Riccardo Haupt, Roberto Rondelli, Roberto Rondelli, Roberto Targhetta, Rosaria Maria Valenti, Santina Cannizzaro, Santina Cannizzaro, Serena Risica, Stefania Varotto, Stefano Mattioli, Stefano Mattioli, Stefano Parodi, Susanna Lagorio, Susanna Lagorio, Ursula Kirchmayer, Veronica Casotto, Vincenzo Poggi, Vittorio Bocchini   +79 more
core   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

A phase I/II study of the combination of quizartinib with azacitidine or low-dose cytarabine for the treatment of patients with acute myeloid leukemia and myelodysplastic syndrome

Haematologica, 2021
FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation in acute myeloid leukemia (AML) is associated with poor prognosis. We hypothesized that quizartinib, a selective and potent FLT3 inhibitor, with azacitidine (AZA) or low-dose ...
Mahesh Swaminathan, Hagop M Kantarjian, Mark Levis, Veronica Guerra, Gautam Borthakur, Yesid Alvarado, Courtney D DiNardo, Tapan Kadia, Guillermo Garcia-Manero, Maro Ohanian, Naval Daver, Marina Konopleva, Naveen Pemmaraju, Alessandra Ferrajoli, Michael Andreeff, Nitin Jain, Zeev Estrov, Elias J Jabbour, William G Wierda, Sherry Pierce, Maria Rhona Pinsoy, Lianchun Xiao, Farhad Ravandi, Jorge E Cortes   +23 more
doaj   +1 more source

Breaking Down the Hierarchy: A New Approach to Leukemia Classification [PDF]

Lecture Notes in Computer Science (LNCS,volume 14313) - 2023
The complexities inherent to leukemia, multifaceted cancer affecting white blood cells, pose considerable diagnostic and treatment challenges, primarily due to reliance on laborious morphological analyses and expert judgment that are susceptible to errors.
arxiv   +1 more source