Results 111 to 120 of about 4,796,691 (248)

Leukemia inhibitory factor is immunomodulatory

, 2008
Leukemia inhibitory factor (LIF) is produced by infiltrating immune cells and glial cells during auto-immune and injury responses in the central nervous system (CNS). During these responses, LIF promotes survival of glial cells and neurons. While various
Carmans, Sofie, de Vries, E., Stinissen, Piet, Hendriks, Jerome J. A., Slaets, Leen, Dijkstra, C., Hellings, Niels   +6 more
core   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Cloning, Expression, and Functional Characterization of In-House Prepared Human Leukemia Inhibitory Factor [PDF]

Cell Journal, 2013
Objective: Leukemia inhibitory factor (LIF) plays important roles in cellular proliferation, growth promotion and differentiation of various types of target cells.
Hassan Rassouli, Shiva Nemati, Siamak Rezaeiani, Ali Sayadmanesh, Mohammad Reza Gharaati, Ghasem Hosseini Salekdeh, Hossein Baharvand, Hamid Gourabi   +7 more
doaj  

Family-based Association Study of Killer Cell Immunoglobulin-Like Receptor Genes with Leukemia

Acta Medica Bulgarica, 2019
NK cell function is controlled by the cell expression of killer immunoglobulin-like receptors (KIRs) and their ligation with the corresponding HLA ligands.
Varbanova V., Mihaylova S., Naumova E., Cotoc C., Mihaylova A.   +4 more
doaj   +1 more source

Natural and semisynthetic bile acids as Leukemia Inhibitory Factor (LIF) receptor antagonists

Leukaemia Inhibitory Factor (LIF) is a pleiotropic member of interleukine (IL)-6 cytokine family,1 that regulates cell differentiation, proliferation and survival in embryo and adult cells and is involved in cancer growth and progression.
Claudia Finamore, Pasquale Rapacciuolo, Stefano Fiorucci, Cristina Di Giorgio, Valentina Sepe, Maria Chiara Monti, Bruno Catalanotti, Angela Zampella   +7 more
core  

Infrequent Wnt inhibitory factor-1 (Wif-1) methylation in chronic lymphocytic leukemia

, 2006
The Wnt pathway has been shown recently, to be activated in patients with chronic lymphocytic leukemia (CLL). This is the first study to examine the role of Wnt inhibitory factor-1 (Wif-1) methylation in the pathogenesis of haematolymphoid malignancies ...
Fung, TK, Chim, CS, Lau, JS, Liang, R, Wong, KF   +4 more
core   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis

, 2002
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barre syndrome (GBS). Treatment with
Laura, M, Curmi, Y, Gregson, N A, Hughes, R A C   +3 more
core   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source