Results 121 to 130 of about 129,713 (294)

Family-based Association Study of Killer Cell Immunoglobulin-Like Receptor Genes with Leukemia

Acta Medica Bulgarica, 2019
NK cell function is controlled by the cell expression of killer immunoglobulin-like receptors (KIRs) and their ligation with the corresponding HLA ligands.
Varbanova V., Mihaylova S., Naumova E., Cotoc C., Mihaylova A.   +4 more
doaj   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Natural and semisynthetic bile acids as Leukemia Inhibitory Factor (LIF) receptor antagonists

Leukaemia Inhibitory Factor (LIF) is a pleiotropic member of interleukine (IL)-6 cytokine family,1 that regulates cell differentiation, proliferation and survival in embryo and adult cells and is involved in cancer growth and progression.
Claudia Finamore, Pasquale Rapacciuolo, Stefano Fiorucci, Cristina Di Giorgio, Valentina Sepe, Maria Chiara Monti, Bruno Catalanotti, Angela Zampella   +7 more
core  

Hepatocyte growth factor and leukemia inhibitory factor treatment increases the mitosis of satellite cells in vivo during hypoxia.

, 2014
Tibialis anterior sections were incubated with antibodies specific for satellite cell marker Pax7, proliferation marker Ki67 and DNA synthesis marker BrdU.
John Vissing (428273), Simon Hauerslev (428271), Thomas O. Krag (428274)   +2 more
core   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Expression of Leukemia Inhibitory Factor and Its Receptor in Preimplantation Embryos

, 2009
Expression of leukemia inhibitory factor and its receptor in preimplantation embryos. Chen HF, Shew JY, Ho HN, Hsu WL, Yang YS Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei.
CHEN, HSIN-FU;SHEW, JIN-YUH;HO, HONG-NERNG;HSU, WEI-LI;YANG, YU-SHIH, 陳信孚;許金玉;何弘能;徐維莉;楊友仕   +1 more
core   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes

, 2010
Stromal cells from pediatric myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) associated with MDS(MDS-AML) present high expression of leukemia inhibitor factor (LIF).
ARANTES, Camila, JUNQUEIRA, Mara Souza, ROELA, Rosimeire A., COSTA, Simone V. da, BRENTANI, M. Mitzi   +4 more
core   +1 more source