Results 101 to 110 of about 155,017 (308)

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

, 2016
To better understand how the apoptosis repressor with caspase recruitment domain (ARC) protein confers drug resistance in acute myeloid leukemia (AML), we investigated the role of ARC in regulating leukemia-mesenchymal stromal cell (MSC) interactions. In
Mak, Po Yee, Mu, Hong, Andreeff, Michael, Arold, Stefan T., Ladbury, John E., Carter, Bing Z., Jacamo, Rodrigo, Kornblau, Steven, Chen, Ye, Ruvolo, Vivian, Mak, Duncan H., Burks, Jared K.   +11 more
core   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Pruritus as a Presenting Symptom of FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia

Journal of Blood Medicine, 2021
Mohammad Abu-Tineh,1 Esra’a Aljaloudi,2 Mohamed A Yassin1 1Department of Oncology- Hematology and BMT Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar; 2Department of Family Medicine, Hamad Medical Corporation,
Abu-Tineh M, Aljaloudi E, Yassin MA
doaj  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

Blood Cancer Journal, 2023
Bing Z. Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B. Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E. Hughes, Phuong K. Morrow, Torsten Haferlach, Steven Kornblau, Muharrem Muftuoglu, Michael Andreeff   +15 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Prevention and treatment of transformation of myeloproliferative neoplasms to acute myeloid leukemia

Haematologica
Philadelphia-chromosome negative (Ph-neg) myeloproliferative neoplasms (MPNs) are hematopoietic stem disorders with a risk of progression to the accelerated-phase (AP) or blastphase (BP) that is influenced by clinical, pathologic, cytogenetic, and ...
Anand A. Patel, Raajit K. Rampal
doaj   +1 more source

Dendrogram of OTU composition obtained from acute lymphoblastic leukemia-affected children and healthy controls.

, 2014
The dendrogram (left section) indicates the similarity of the microbial communities of supragingival dental plaque between subjects according to their OTU composition, as determined using the Jaccard index (MOTHUR).
Xuedong Zhou (296256), Xin Xu (11989), Qin Du (170006), Meng You (598280), Lei Cheng (171055), Xue Yang (144876), Jing Zou (550318), Wenyuan Shi (180327), Jingzhi He (598281), Jing Xue (170229), Yan Wang (15435), Mingyun Li (598282), Yiping Zhu (157710), Yuqing Li (28192), Jiyao Li (598283)   +14 more
core   +1 more source

A Case Report of a Patient with a Rare and Aggressive Plasma Cell Leukemia [PDF]

, 2017
Plasma cell leukemia (PCL) is the most aggressive form of the plasma cell dyscrasias. This rare disease remains a challenge in regard to diagnosis and treatment due to its rarity and aggressive nature.
Ami Ashariati, Ugroseno Yudho Bintoro, Putu Niken Amrita, Made Putra Sadana, Raharjo Budiono, Ami Ashariati Prayoga, Made Putra Sedana, Siprianus Ugroseno Yudho Bintoro   +7 more
core   +1 more source