Results 81 to 90 of about 155,017 (308)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Leucemia linfoblástica aguda em lactentes: 20 anos de experiência em um serviço de referência estadual [PDF]

, 2012
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Seiben, Jackline
core  

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

A cross-sectional analysis of the global burden of childhood leukemia from 1990 to 2021

Journal of Cancer Research and Clinical Oncology
Childhood leukemia is a common malignant tumor worldwide, affecting survival rates and posing medical and public health challenges. Assessing its global burden is essential for informing prevention, treatment, and policy efforts.This is a cross-sectional study based on data from the 2021 Global Burden of Disease (GBD) study, covering the years 1990 to ...
Wang, Ping, Cui, Jianing, Ni, ZiHao, Qian, Zhanhua, Zhan, Huili, Zhang, Heng, Ye, Wei, Meng, Wei, Bai, Rongjie   +8 more
openaire   +2 more sources

Studies on Leukemia Part 1. Clicical Statistics of Leukemia Occuring in the Chugoku-Shikoku District Section 1. General Statistics [PDF]

, 1959
On 822 cases collected from the death certificates. the suthor studied the trend of leukemia occurring in the ChugokuShikoku Distric (excluding Hiroshima Prefecture) during the period from 1951 up to June 1957, and obtained the following results.
Wakimoto, Takeo
core  

Acute leukemia in pregnancy with ovarian metastasis: a case report and review of the literature

, 2003
Acute leukemias tend to affect a younger population and are much more common in pregnant patients than chronic leukemias are. We report a case of acute lymphoblastic leukemia diagnosed during the third trimester presenting with organomegaly and ...
Terek, MC, Erhan, Y, Zekioglu, O, Pehlivan, M, Cagirgan, S, Özkınay, E, Mgoyi, L   +6 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Birth Outcome and Maternal Risk Factors Associated with Childhood Leukemia in Rwanda: A case - Control Study

, 2022
BackgroundLeukemia is the most common cancer affecting children and remains the top cause of death among children.ObjectiveThis study aimed at determining birth outcomes and maternal risk factors associated with childhood leukemia in Rwanda.MethodsA case
Turatsinze, Felicien, Habtu, Michael, Rutayisire, Erigene   +2 more
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Neoplasias de células linfoides maduras B: avaliação dos casos diagnosticados e acompanhados no hospital universitário da Universidade Federal de Santa Catarina entre 2011 e 2014 [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.De acordo com a classificação da OMS (2008), as neoplasias de células maduras B (NCLM-B) abrangem os ...
Cardoso, Chandra Chiappin
core