Results 71 to 80 of about 155,017 (308)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Tissue Culture and Circulating Myeloblasts of Avian Leukemia Studied in Electron Micrographs of Ultrathin Sections.

Experimental Biology and Medicine, 1958
SummaryStudies have been made by electron microscopic examination of ultrathin sections of circulating myeloblasts of avian myeloblastosis and of these cells in tissue culture. Examinations were made, also, of tissues of spleen, bone marrow and liver of the diseased birds.
D F, PARSONS, J C, PAINTER, G S, BEAUDREAU, C, BECKER, J W, BEARD   +4 more
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effect of tyrosine kinase inhibitors on male fertility in patients with chronic phase chronic myeloid leukemia

Supplemental material is available online at: https://www.tandfonline.com/doi/full/10.1080/10428194.2024.2343758#supplemental-material-section .Advancements in the management of patients with chronic myeloid leukemia (CML) allowed them to achieve ...
Jayasena, C, Szydlo, R, Nesr, G, Apperley, J, Lovato, S, Claudiani, S, Caballes, I, Innes, A, Fernando, F, Mungozi, P, Milojkovic, D   +10 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Venetoclax for AML: changing the treatment paradigm

Blood Advances, 2019
: Venetoclax is a specific B-cell lymphoma-2 (BCL-2) inhibitor that can restore activation of apoptosis in malignancies, the survival of which depends on dysregulation of this pathway.
Daniel A. Pollyea, Maria Amaya, Paolo Strati, Marina Y. Konopleva   +3 more
doaj   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Knowledge, attitude, and practice toward leukemia in the general population and among family members of patients with leukemia: A cross-sectional study

Heliyon
Patients with leukemia rely on social and family support. This study aimed to explore the knowledge, attitude, and practice (KAP) toward leukemia among family members of patients with leukemia and the general population in southeast China.A cross-sectional study was conducted in September 2022 in southeast China (Anhui Province).
Fengbo Jin, Wanlu Tian, Leiming Xia, Mingzhen Yang, Yingying Chen, Jianjun Li, Lixia Liu   +6 more
openaire   +3 more sources

Studies on Leukemia Part 2. Cliuical Statistics of Leukemia Occuring in the Chugoku-Shikoku District Section 2. Characteristics of Type [PDF]

, 1959
With the Purpose to clarify the characteristics in each type of leukemia, the author analyzed the 822 ca es of leukemia collected from the death certificates in the Chugoku-Shikoku District (excluding Hiroshima Prefecture) during the period from 1951 to ...
Wakimoto, Takeo
core