Results 51 to 60 of about 155,017 (308)

FACTORS INFLUENCING ADHERENCE TO IMATINIB IN INDIAN CHRONIC MYELOID LEUKEMIA PATIENTS: A CROSS-SECTIONAL STUDY [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2015
Adherence to imatinib(IM) is of utmost importance in patients with chronic myeloid leukemia(CML) to maximise treatment effectiveness. The main objective is to measure adherence to    IM & to evaluate individual patient characteristics, personal, treatment related &                    psychological factors influencing adherence behaviour ...
Jyotsna Kapoor, Narendra Agrawal, Rayaz Ahmad, Sanjeev Kumar Sharma, Anshul Gupta, Dinesh Bhurani   +5 more
openaire   +3 more sources

Determinants of Quality of Life in Family Caregivers of Patients With Leukemia: A Cross-Sectional Study

Sage Open, 2023
This study aimed to determine the quality of life of family caregivers of patients with leukemia and the factors contributing to it. The RAND 36-Item was used to collect data from 152 caregivers. The mean scores of six dimensions of Quality of life (QoL) were low, indicating a limited health state.
Nahla M. Al Ali, Amjad Eid, Nabela Aljada   +2 more
openaire   +2 more sources

Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML

Translational Oncology, 2022
Tyrosine kinase inhibitors (TKIs) are established drugs in the therapy of FLT3-ITD mutated acute myeloid leukemia (AML). However, acquired mutations, such as D835 in the tyrosine kinase domain (FLT3-ITD/D835), can induce resistance to TKIs.
Kotoko Yamatani, Tomohiko Ai, Kaori Saito, Koya Suzuki, Atsushi Hori, Sonoko Kinjo, Kazuho Ikeo, Vivian Ruvolo, Weiguo Zhang, Po Yee Mak, Bogumil Kaczkowski, Hironori Harada, Kazuhiro Katayama, Yoshikazu Sugimoto, Jered Myslinski, Takashi Hato, Takashi Miida, Marina Konopleva, Yoshihide Hayashizaki, Bing Z. Carter, Yoko Tabe, Michael Andreeff   +21 more
doaj   +1 more source

High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure

Leukemia Research Reports, 2014
Dual differentiation therapy with arsenic trioxide and tretinoin (all-trans-retinoic acid; ATRA) for the management of low and intermediate risk acute promyelocytic leukemia has recently been recommended by the National Comprehensive Cancer Network. Some
Morgan B. Smith, Elizabeth A. Griffiths, James E. Thompson, Eunice S. Wang, Meir Wetzler, Craig W. Freyer   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Protocol for monitoring clonal hematopoiesis in transgenic mouse models using multispectral imaging

STAR Protocols
Summary: Clonal hematopoiesis involves the clonal expansion of hematopoietic cells, potentially progressing into hematological malignancies. Here, we present a protocol for the development and characterization of two mouse models designed to simulate ...
Priyanka Khanna, Lauren B. Ostermann, Shayaun Khazaei, Ran Zhao, Michael Andreeff, Rasoul Pourebrahim   +5 more
doaj   +1 more source

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Haematologica, 2017
Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine kinase anexelekto is critical for FMS-like tyrosine kinase 3 signaling and participates in FMS ...
Peter P. Ruvolo, Huaxian Ma, Vivian R. Ruvolo, Xiaorui Zhang, Hong Mu, Wendy Schober, Ivonne Hernandez, Miguel Gallardo, Joseph D. Khoury, Jorge Cortes, Michael Andreeff, Sean M. Post   +11 more
doaj   +1 more source

Extraction of dynamic patterns from static rna expression data: an application to hematological neoplasms [PDF]

, 2012
Within the study of pathological conditions from the analysis of high-throughput data, the usual approach consists in using supervised classification algorithms. Such approach frequently fails due to the initial bias of class definition uncertainty.
Bianchi, Giulia
core  

Segmentation System of Acute Myeloid Leukemia (AML) Subtypes on Microscopic Blood Smear Image [PDF]

, 2020
Leukemia is a blood cancer that attacks human white blood cells. This disease is divided into four types, including Acute Myeloid Leukemia (AML). AML is the most common type of acute leukemia, and it has eight types of subtypes distinguished by the level
Riyanto Sigit, Nur Khomairoh, Tri Harsono, Yetti Hernaningsih, Anwar Anwar, Anwar   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source