Results 31 to 40 of about 155,038 (165)

Current trends in acute leukemia: A cross-sectional survey of adult acute leukemia cases

LIAQUAT MEDICAL RESEARCH JOURNAL
Acute Leukemia (AL) is one of the cancer on rise globally, there is dearth of regional information in particular gender pattern of the disease among adult population from Pakistan. Therefore, this cross-sectional study was designed and conducted at Medical Oncology department at Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
Sorath Bhutto, Ghulam Haider, Sana Hashmat, Nargis Alam, Saima Zahoor, Shayan Ali Qazi, Areeba Qureshi   +6 more
openaire   +2 more sources

FACTORS INFLUENCING ADHERENCE TO IMATINIB IN INDIAN CHRONIC MYELOID LEUKEMIA PATIENTS: A CROSS-SECTIONAL STUDY [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2015
Adherence to imatinib(IM) is of utmost importance in patients with chronic myeloid leukemia(CML) to maximise treatment effectiveness. The main objective is to measure adherence to    IM & to evaluate individual patient characteristics, personal, treatment related &                    psychological factors influencing adherence behaviour ...
Jyotsna Kapoor, Narendra Agrawal, Rayaz Ahmad, Sanjeev Kumar Sharma, Anshul Gupta, Dinesh Bhurani   +5 more
openaire   +3 more sources

Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML

Translational Oncology, 2022
Tyrosine kinase inhibitors (TKIs) are established drugs in the therapy of FLT3-ITD mutated acute myeloid leukemia (AML). However, acquired mutations, such as D835 in the tyrosine kinase domain (FLT3-ITD/D835), can induce resistance to TKIs.
Kotoko Yamatani, Tomohiko Ai, Kaori Saito, Koya Suzuki, Atsushi Hori, Sonoko Kinjo, Kazuho Ikeo, Vivian Ruvolo, Weiguo Zhang, Po Yee Mak, Bogumil Kaczkowski, Hironori Harada, Kazuhiro Katayama, Yoshikazu Sugimoto, Jered Myslinski, Takashi Hato, Takashi Miida, Marina Konopleva, Yoshihide Hayashizaki, Bing Z. Carter, Yoko Tabe, Michael Andreeff   +21 more
doaj   +1 more source

Determinants of Quality of Life in Family Caregivers of Patients With Leukemia: A Cross-Sectional Study

Sage Open, 2023
This study aimed to determine the quality of life of family caregivers of patients with leukemia and the factors contributing to it. The RAND 36-Item was used to collect data from 152 caregivers. The mean scores of six dimensions of Quality of life (QoL) were low, indicating a limited health state.
Nahla M. Al Ali, Amjad Eid, Nabela Aljada   +2 more
openaire   +2 more sources

High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure

Leukemia Research Reports, 2014
Dual differentiation therapy with arsenic trioxide and tretinoin (all-trans-retinoic acid; ATRA) for the management of low and intermediate risk acute promyelocytic leukemia has recently been recommended by the National Comprehensive Cancer Network. Some
Morgan B. Smith, Elizabeth A. Griffiths, James E. Thompson, Eunice S. Wang, Meir Wetzler, Craig W. Freyer   +5 more
doaj   +1 more source

Protocol for monitoring clonal hematopoiesis in transgenic mouse models using multispectral imaging

STAR Protocols
Summary: Clonal hematopoiesis involves the clonal expansion of hematopoietic cells, potentially progressing into hematological malignancies. Here, we present a protocol for the development and characterization of two mouse models designed to simulate ...
Priyanka Khanna, Lauren B. Ostermann, Shayaun Khazaei, Ran Zhao, Michael Andreeff, Rasoul Pourebrahim   +5 more
doaj   +1 more source

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Haematologica, 2017
Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine kinase anexelekto is critical for FMS-like tyrosine kinase 3 signaling and participates in FMS ...
Peter P. Ruvolo, Huaxian Ma, Vivian R. Ruvolo, Xiaorui Zhang, Hong Mu, Wendy Schober, Ivonne Hernandez, Miguel Gallardo, Joseph D. Khoury, Jorge Cortes, Michael Andreeff, Sean M. Post   +11 more
doaj   +1 more source

Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative breast cancer

npj Breast Cancer
Gangliosides are acidic glycosphingolipids involved in cell-adhesion, signal-transduction and tumor progression. GD3 synthase (GD3S/ST8SIA1), a key enzyme in ganglioside biosynthesis, is upregulated in many cancers, including GD2+ breast cancer stem-like
Vivek Anand, Bolutyfe Oderinde, Maryam Siddiqui, Anudishi Tyagi, Jenny Borgman, Chong Wu, Michael Andreeff, V. Lokesh Battula   +7 more
doaj   +1 more source

Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis

Haematologica, 2018
The bone marrow microenvironment, also known as the bone marrow niche, is a complex network of cell types and acellular factors that supports normal hematopoiesis.
Phuong M. Le, Michael Andreeff, Venkata Lokesh Battula   +2 more
doaj   +1 more source

Tissue Culture and Circulating Myeloblasts of Avian Leukemia Studied in Electron Micrographs of Ultrathin Sections.

Experimental Biology and Medicine, 1958
SummaryStudies have been made by electron microscopic examination of ultrathin sections of circulating myeloblasts of avian myeloblastosis and of these cells in tissue culture. Examinations were made, also, of tissues of spleen, bone marrow and liver of the diseased birds.
D F, PARSONS, J C, PAINTER, G S, BEAUDREAU, C, BECKER, J W, BEARD   +4 more
openaire   +2 more sources