Results 31 to 40 of about 155,017 (308)

Baricitinib with cyclosporine eliminates acute graft rejection in fully mismatched skin and heart transplant models

Frontiers in Immunology, 2023
Solid organ transplant represents a potentially lifesaving procedure for patients suffering from end-stage heart, lung, liver, and kidney failure.
Ramzi Abboud, Sena Kim, Karl Staser, Reyka G. Jayasinghe, Sora Lim, Parmeshwar Amatya, C. Corbin Frye, Benjamin Kopecky, Julie Ritchey, Feng Gao, Kory Lavine, Daniel Kreisel, John F. DiPersio, Jaebok Choi   +13 more
doaj   +1 more source

Acute Leukemia [PDF]

, 2011
This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease.

core   +1 more source

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and re-sensitizes acute myeloid leukemia to BCL-2 inhibition

Haematologica, 2020
MCL-1 and BCL-2 are both frequently overexpressed in acute myeloid leukemia (AML) and critical for the survival of AML cells and AML stem cells. MCL-1 is a key factor in venetoclax resistance.
Bing Z. Carter, Po Yee Mak, Wenjing Tao, Marc Warmoes, Philip L. Lorenzi, Duncan Mak, Vivian Ruvolo, Lin Tan, Justin Cidado, Lisa Drew, Michael Andreeff   +10 more
doaj   +1 more source

DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia

Scientific Reports, 2021
Peposertib (M3814) is a potent and selective DNA-PK inhibitor in early clinical development. It effectively blocks non-homologous end-joining repair of DNA double-strand breaks (DSB) and strongly potentiates the antitumor effect of ionizing radiation (IR)
Eric Haines, Yuki Nishida, Michael I. Carr, Rafael Heinz Montoya, Lauren B. Ostermann, Weiguo Zhang, Frank T. Zenke, Andree Blaukat, Michael Andreeff, Lyubomir T. Vassilev   +9 more
doaj   +1 more source

Acute Lymphoblastic Leukemia Blood Cells Prediction Using Deep Learning & Transfer Learning Technique

, 2023
White blood cells called lymphocytes are the target of the blood malignancy known as acute lymphoblastic leukemia (ALL). In the domain of medical image analysis, deep learning and transfer learning methods have recently showcased significant promise ...
Ghongade, Omkar Subhash; SRM University-AP, Amaravati, India, Tokala, Srilatha; SRM University-AP, Amaravati, India, Reddy, S Kiran Sai; SRM University-AP, Amaravati, India, Enduri, Murali Krishna; SRM University AP, Gavini, Yaswanth Chowdary; SRM University-AP, Amaravati, India   +4 more
core   +1 more source

Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial

Haematologica, 2018
Targeted therapies against FLT3-mutated acute myeloid leukemias have shown limited clinical efficacy primarily because of the acquisition of secondary mutations in FLT3 and persistent activation of downstream pro-survival pathways such as MEK/ERK, PI3K ...
Weiguo Zhang, Charlie Ly, Jo Ishizawa, Hong Mu, Vivian Ruvolo, Sharon Shacham, Naval Daver, Michael Andreeff   +7 more
doaj   +1 more source

Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model

Haematologica, 2020
Although highly effective, BCR-ABL1 tyrosine kinase inhibitors do not target chronic myeloid leukemia (CML) stem cells. Most patients relapse upon tyrosine kinase inhibitor therapy cessation.
Bing Z. Carter, Po Yee Mak, Hong Mu, Xiangmeng Wang, Wenjing Tao, Duncan H. Mak, Elisha J. Dettman, Michael Cardone, Oleg Zernovak, Takahiko Seki, Michael Andreeff   +10 more
doaj   +1 more source

Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models

Frontiers in Immunology, 2022
Immunotherapy with T-cells expressing bispecific T-cell engagers (ENG T-cells) is a promising approach to improve the outcomes for patients with recurrent/refractory acute myeloid leukemia (AML).
Hong Mu-Mosley, Lauren Ostermann, Muharrem Muftuoglu, Abishek Vaidya, Challice L. Bonifant, Mireya Paulina Velasquez, Stephen Gottschalk, Michael Andreeff   +7 more
doaj   +1 more source

Influencing factors of cancer-related fatigue in acute leukemia patients: A cross-sectional study

Heliyon, 2023
To investigate influencing factors of cancer-related fatigue (CRF) in adult patients with acute leukemia (AL).A total of 288 adult patients diagnosed with acute leukemia in West China Hospital were included in this study. A cross-sectional survey, including the Clinical Information Questionnaire, the Functional Assessment of Chronic Illness Therapy ...
Yingli Wang, Xinwen Du, Yuping Gong, Yan Jiang, Yuhuan Zheng   +4 more
openaire   +3 more sources

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase [PDF]

, 2009
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism.
Vaskar Saha, Krishnan, S., Holland, Mark, Colin Watts, Mark Holland, Holland, M., Liu, JiZhong, Ariffin, Hany, Bates, P.A., Marcin Krol, Paul A. Bates, Moss, Catherine X., Patel, N., Essink, M., Patel, Naina, Clare Dempsey, Krishnan, Shekhar, van Delft, Frederik W., Watts, Colin, Carly Leighton, Leighton, Carly, Eden, T.O.B., Moss, C.X., Offman, Marc N., JiZhong Liu, Dempsey, Clare, Seema Alexander, Hany Ariffin, Bates, Paul A., Dempsey, C., Eden, Tim O B, Alexander, S., van Delft, F.W., Frederik W. van Delft, Watts, C., Offman, M.N., Saha, V., Leighton, C., Eden, Tim O.B., Saha, Vaskar; id_orcid, Shekhar Krishnan, Monika Essink, Saha, Vaskar, Krol, Marcin, Ariffin, H., Tim O.B. Eden, Naina Patel, Alexander, Seema, Catherine X. Moss, Krol, M., Marc N. Offman, Liu, J.Z., Essink, Monika   +52 more
core   +1 more source