Results 41 to 50 of about 155,017 (308)

Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival

Haematologica, 2018
Mesenchymal stromal cells (MSC) support acute myeloid leukemia (AML) cell survival in the bone marrow (BM) microenvironment. Protein expression profiles of AML-derived MSC are unknown.
Steven M. Kornblau, Peter P. Ruvolo, Rui-Yu Wang, V. Lokesh Battula, Elizabeth J. Shpall, Vivian R. Ruvolo, Teresa McQueen, YiHua Qui, Zhihong Zeng, Sherry Pierce, Rodrigo Jacamo, Suk-Young Yoo, Phuong M. Le, Jeffrey Sun, Numsen Hail, Marina Konopleva, Michael Andreeff   +16 more
doaj   +1 more source

Superoxide Dismutase and Vitamin E Levels in Serum as Indicators in Patients with Acute and Chronic Leukemia [PDF]

Journal of Applied Sciences and Nanotechnology, 2022
Oxidative stress has been linked to the development of a variety of malignancies, including leukemia. Furthermore, the incidence of leukemia increases with age due to an increase in the number of free radicals reacting with age and a lower ability of the
Reem Al-Qaisi, Abdulnasser Al-Gebori, Mohammed Alosami   +2 more
doaj   +1 more source

Acute Myeloid Leukemia, Version 2.2013 [PDF]

, 2013
These NCCN Guidelines Insights summarize several key updates to the NCCN Guidelines for Acute Myeloid Leukemia and discuss the clinical evidence that support the recommendations.
Paul J. Shami, Margaret R. O’Donnell, Arber, Daniel A, Jessica K. Altman, Millenson, Michael M, Attar, Eyal, Borate, Uma, Appelbaum, Frederick R, Strickland, Stephen A, Damon, Lloyd E, Eunice S. Wang, Michael G. Martin, Lancet, Jeffrey, Jeffrey Lancet, Richard M. Stone, Wang, Eunice S, Stephen A. Strickland, Moore, Joseph O, Martin S. Tallman, Camille N. Abboud, Smith, B Douglas, Shami, Paul J, Maness, Lori J, Daniel A. Arber, Kristina M. Gregory, Marcucci, Guido, Martin, Michael G, Ravandi, Farhad, O'Donnell, Margaret R, Lloyd E. Damon, Frederick R. Appelbaum, Eyal Attar, Steven E. Coutre, Maoko Naganuma, Tallman, Martin S, Altman, Jessica K, Naganuma, Maoko, Abboud, Camille N, Gregory, Kristina M, Lori J. Maness, Joseph O. Moore, Uma Borate, Guido Marcucci, B. Douglas Smith, Farhad Ravandi, Coutre, Steven E, Michael M. Millenson, Stone, Richard M   +47 more
core   +1 more source

The Regulation of Neutrophil Migration in Patients with Sepsis: The Complexity of the Molecular Mechanisms and Their Modulation in Sepsis and the Heterogeneity of Sepsis Patients

Cells, 2023
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Common causes include gram-negative and gram-positive bacteria as well as fungi.
Øystein Bruserud, Knut Anders Mosevoll, Øyvind Bruserud, Håkon Reikvam, Øystein Wendelbo   +4 more
doaj   +1 more source

The Current Understanding of and Treatment Paradigm for Newly-Diagnosed TP53-Mutated Acute Myeloid Leukemia

Hemato, 2021
About 10% of newly diagnosed and 20–30% of therapy-related acute myeloid leukemia (AML) harbors a TP53 mutation (mTP53-AML). Unfortunately, this biological subset predicts one of the worst prognoses among patients with AML, specifically a median overall ...
Rory M. Shallis, Maximilian Stahl, Jan Philipp Bewersdorf, Amer M. Zeidan   +3 more
doaj   +1 more source

Extending the duration of response in chronic myelogenous leukemia: targeted therapy with sequential tyrosine kinase inhibitors

Oncology Reviews, 2011
Tyrosine kinase inhibitors (TKIs) are the mainstay for treatment of chronic myelogenous leukemia (CML). Imatinib was the first TKI approved for use in CML, but resistance to this therapy has emerged as a significant issue, and second-line options are ...
Michael G. Martin, John F. DiPersio, Geoffrey L. Uy   +2 more
doaj   +1 more source

Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang

Cancer Biology & Medicine, 2016
Acute myeloid leukemia (AML) is characterized by the accumulation of circulating immature blasts that exhibit uncontrolled growth, lack the ability to undergo normal differentiation, and have decreased sensitivity to apoptosis.
Hong-Sheng Zhou, Bing Z. Carter, Michael Andreeff   +2 more
doaj   +1 more source

Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California [PDF]

, 2017
The relationship of mode of delivery to risk of childhood acute lymphoblastic leukemia (ALL) is uncertain. After linking birth records and cancer registry data from California, we conducted a population-based case-control study to investigate the role of
Zhang, Yawei, Metayer, Catherine, Wiemels, Joseph L, Francis, Stephen S, Wang, Rong, Ma, Xiaomei, Kadan-Lottick, Nina, Morimoto, Libby, DeWan, Andrew T   +8 more
core   +1 more source

Targeting Bruton’s Tyrosine Kinase in CLL

Frontiers in Immunology, 2021
Targeting the B-cell receptor signaling pathway through BTK inhibition proved to be effective for the treatment of chronic lymphocytic leukemia (CLL) and other B-cell lymphomas.
Inhye E. Ahn, Jennifer R. Brown
doaj   +1 more source

Current trends in acute leukemia: A cross-sectional survey of adult acute leukemia cases

LIAQUAT MEDICAL RESEARCH JOURNAL
Acute Leukemia (AL) is one of the cancer on rise globally, there is dearth of regional information in particular gender pattern of the disease among adult population from Pakistan. Therefore, this cross-sectional study was designed and conducted at Medical Oncology department at Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.
Sorath Bhutto, Ghulam Haider, Sana Hashmat, Nargis Alam, Saima Zahoor, Shayan Ali Qazi, Areeba Qureshi   +6 more
openaire   +2 more sources