Results 31 to 40 of about 277,018 (298)
Cells, 2023 Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Common causes include gram-negative and gram-positive bacteria as well as fungi.
Øystein Bruserud +4 more
doaj +1 more source
Assessing similarity of feature selection techniques in high-dimensional domains [PDF]
, 2013 Recent research efforts attempt to combine multiple feature selection techniques instead of using a single one. However, this combination is often made on an “ad hoc” basis, depending on the specific problem at hand, without considering the degree of ...
CANNAS LM +2 more
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FACTORS INFLUENCING ADHERENCE TO IMATINIB IN INDIAN CHRONIC MYELOID LEUKEMIA PATIENTS: A CROSS-SECTIONAL STUDY [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2015 Adherence to imatinib(IM) is of utmost importance in patients with chronic myeloid leukemia(CML) to maximise treatment effectiveness. The main objective is to measure adherence to IM & to evaluate individual patient characteristics, personal, treatment related & psychological factors influencing adherence behaviour ...
Jyotsna Kapoor +5 more
openaire +3 more sources
Spectral gene set enrichment (SGSE) [PDF]
, 2014 Motivation: Gene set testing is typically performed in a supervised context to quantify the association between groups of genes and a clinical phenotype. In many cases, however, a gene set-based interpretation of genomic data is desired in the absence of
Frost, H. Robert +2 more
core +3 more sources
Cancer Reports, 2022 AbstractBackgroundA cross‐sectional nationwide study was designed to assess national compliance with international consensus/guidelines of monitoring asparaginase levels in children with acute lymphoblastic leukemia (ALL) treated with asparaginase in routine clinical practice.MethodsAn ad hoc questionnaire was designed and completed by staff physicians
Lassaletta, Álvaro +2 more
openaire +4 more sources
Hemato, 2021 About 10% of newly diagnosed and 20–30% of therapy-related acute myeloid leukemia (AML) harbors a TP53 mutation (mTP53-AML). Unfortunately, this biological subset predicts one of the worst prognoses among patients with AML, specifically a median overall ...
Rory M. Shallis +3 more
doaj +1 more source
Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
Oncology Reviews, 2011 Tyrosine kinase inhibitors (TKIs) are the mainstay for treatment of chronic myelogenous leukemia (CML). Imatinib was the first TKI approved for use in CML, but resistance to this therapy has emerged as a significant issue, and second-line options are ...
Michael G. Martin +2 more
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Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang
Cancer Biology & Medicine, 2016 Acute myeloid leukemia (AML) is characterized by the accumulation of circulating immature blasts that exhibit uncontrolled growth, lack the ability to undergo normal differentiation, and have decreased sensitivity to apoptosis.
Hong-Sheng Zhou +2 more
doaj +1 more source
Mass concentration in a nonlocal model of clonal selection [PDF]
, 2016 Self-renewal is a constitutive property of stem cells. Testing the cancer stem cell hypothesis requires investigation of the impact of self-renewal on cancer expansion. To understand better this impact, we propose a mathematical model describing dynamics
Busse, Jan-Erik +2 more
core +1 more source