Results 71 to 80 of about 277,018 (298)
A Novel Deep Learning Segmentation and Classification Framework for Leukemia Diagnosis
Algorithms, 2023 Blood cancer occurs due to changes in white blood cells (WBCs). These changes are known as leukemia. Leukemia occurs mostly in children and affects their tissues or plasma. However, it could occur in adults. This disease becomes fatal and causes death if
A. Khuzaim Alzahrani +4 more
doaj +1 more source
Scalable and Accurate Online Feature Selection for Big Data
, 2016 Feature selection is important in many big data applications. Two critical challenges closely associate with big data. Firstly, in many big data applications, the dimensionality is extremely high, in millions, and keeps growing.
Ding, Wei +3 more
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2023 RNA sequencing (RNA-seq) is a reliable tool for detecting gene fusions in acute leukemia. Multiple bioinformatics pipelines have been developed to analyze RNA-seq data, but an agreed gold standard has not been established. This study aimed to compare the
Clara Vicente-Garcés +19 more
doaj +1 more source
The effects of time valuation in cancer optimal therapies: a study of chronic myeloid leukemia [PDF]
, 2019 Background The mathematical design of optimal therapies to fight cancer is an important research field in today’s Biomathematics and Biomedicine given its relevance to formulate patient-specific treatments. Until now, however, cancer optimal therapies
Gutiérrez Díez, Pedro José
core +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Venetoclax for AML: changing the treatment paradigm
Blood Advances, 2019 : Venetoclax is a specific B-cell lymphoma-2 (BCL-2) inhibitor that can restore activation of apoptosis in malignancies, the survival of which depends on dysregulation of this pathway.
Daniel A. Pollyea +3 more
doaj +1 more source
Principal component gene set enrichment (PCGSE) [PDF]
, 2014 Motivation: Although principal component analysis (PCA) is widely used for the dimensional reduction of biomedical data, interpretation of PCA results remains daunting.
Frost, H. Robert +2 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source