Results 91 to 100 of about 112,142 (249)
A Genetic Locus Regulates the Expression of Tissue-Specific mRNAs from Multiple Transcription Units [PDF]
, 1982 129 GIX- mice, unlike animals of the congeneic partner strain GIX+, do not express significant amounts of the retroviral antigens gp70 and p30. Evidence is presented indicating that the GIX phenotype is specified by a distinct regulatory gene acting on ...
Lerner, Richard A. +2 more
core +2 more sources
Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer
Advanced Science, EarlyView.This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo +6 more
wiley +1 more source
Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. [PDF]
, 2006 Cell entry of hepatitis C virus, pseudoparticles (HCVpp) and cell culture grown virus (HCVcc), requires the interaction of viral glycoproteins with CD81 and other as yet unknown cellular factors.
Boullier, Agnès +6 more
core +1 more source
Biotechnology Progress, EarlyView.Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal +5 more
wiley +1 more source
Bovine leukemia virus discovered in human blood
BMC Infectious Diseases, 2019 Background Bovine leukemia virus (BLV) infection is widespread in cattle globally and is present in marketed beef and dairy products. Human infection with BLV has been reported in breast and lung cancer tissues and was significantly associated with ...
Gertrude C. Buehring +7 more
doaj +1 more source
Pathobiology of bovine leukemia virus.
Veterinary research, 1994 Bovine leukemia virus (BLV) is a retrovirus similar to the human T-cell leukemia virus (HTLV). Most BLV infected animals (70%) develop a B-cell lymphoproliferative syndrome with altered productive traits and 1 to 5% die with B-cell lymphosarcomas. Although BLV infection is world-wide, western European countries have almost eradicated it by slaughtering
Schwartz-Cornil, Isabelle +1 more
openaire +4 more sources
Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review
Clinical Anatomy, EarlyView.ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley +1 more source
Veterinary Medicine International, 2012 Enzootic bovine leukosis is a contagious disease of cattle caused by the retrovirus, bovine leukemia virus (BLV) and is the most common cause of malignant neoplasm in cattle.
Ronald J. Erskine +5 more
doaj +1 more source
Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat [PDF]
, 2009 TRIM5[alpha] mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved ...
Hosie, Margaret J. +5 more
core +2 more sources
ChemMedChem, EarlyView.Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto +12 more
wiley +1 more source