Results 151 to 160 of about 248,987 (332)

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Acute appendicitis in patients suffering from Immunocompromising hematologic malignancies or chemotherapy-related leukopenia: a cohort study

BMC Cancer
Background Acute appendicitis is a common surgical emergency, but its diagnosis can be challenging in patients with hematologic malignancies or chemotherapy-induced leukopenia due to an impaired inflammatory response.
Alexandra C. Klein, Hannah Rasel, Oliver Kriege, Fabian Bartsch, Hauke Lang, Ann-Kathrin Lederer   +5 more
doaj   +1 more source

Non-Dynamic Association of Depressive and Anxiety Disorders With Leukocyte Telomere Length? [PDF]

, 2016
Ezra Susser, Simon Verhulst, Jeremy D. Kark, Pam Factor‐Litvak, Katherine M. Keyes, Per Magnus, Abraham Aviv   +6 more
openalex   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

DNA Banking of Primary Immunodeficiency Disorders in Iran

Iranian Journal of Allergy, Asthma and Immunology, 2006
Primary immunodeficiency disorders are a heterogeneous group of genetic disorders, with different modes of inheritance, consisting of more than 100 different types.
"Anna Isaian, Mostafa Moin, Zahra Pourpak, Nima Rezaei, Asghar Aghamohammadi, Masoud Movahedi, Mohammad Gharagozlou, Javad Ghaffari, Fariborz Zieh, Mahboubeh Mansouri, Abolhassan Farhoudi "   +10 more
doaj  

Leukocyte glutamate dehydrogenase in patients with degenerative neurological disorders. [PDF]

, 1989
Andreas Plaitakis
openalex   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Evaluation of Opsonic and Leukocyte Function With a Spectrophotometric Test in Patients With Infection and With Phagocytic Disorders [PDF]

, 1973
Thomas P. Stossel
openalex   +1 more source

Mental Disorders Are Associated With Leukocytes Telomere Shortening Among People Who Inject Drugs [PDF]

, 2022
Mélusine Durand, Nicolas Nagot, Laurent Michel, Sao Mai Le, Huong Thi Duong, Roselyne Vallo, Amélie Vizeneux, Delphine Rapoud, Hoang Thi Nam Giang, Catherine Quillet, Nham Thi Tuyet Thanh, Khuat Thi Hai Oanh, Vinh Vu Hai, Jonathan Feelemyer, Philippe Van de Perre, Phạm Minh Khuê, Didier Laureillard, Don C. Des Jarlais, Jean‐Pierre Molès   +18 more
openalex   +1 more source