Results 251 to 260 of about 237,141 (361)

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza   +26 more
wiley   +1 more source

Pharmacogenomics in the UK National Health Service: Progress towards implementation

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Over the past decade there has been considerable and growing enthusiasm about the promise of using genomics to inform healthcare. In particular, using genetic data to inform prescribing practice has emerged as a compelling policy priority for health systems around the world, not least in the NHS.
John H. McDermott   +3 more
wiley   +1 more source

Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors. [PDF]

open access: yesFront Aging Neurosci
Barros AGA   +13 more
europepmc   +1 more source

Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health

open access: yesBioEssays, EarlyView.
The microfluidic Cervix Chip is an in vitro model of the human cervix lined by cervical epithelium interfaced with stromal cells cultured under dynamic flow that represents a new preclinical platform for studying mucosal immunity, host‐microbiome interactions, infections, fertility, and pregnancy health.
Zohreh Izadifar   +4 more
wiley   +1 more source

Designing next‐generation immune cell therapies with nanomaterials

open access: yesBMEMat, EarlyView.
Nanomaterials are transforming immune cellular therapies (ICT) by addressing challenges like tumor accessibility and lengthy manufacturing. This perspective highlights innovations such as magnetic nanoparticles for target identification, lipid nanoparticles for T cell stimulation, and nanoparticle‐mediated gene cytokine delivery. These advances promise
Kangfu Chen, Wenhan Wang, Zongjie Wang
wiley   +1 more source

Case Report: Early diagnosis of LAD-III in newborn with persistent leukocytosis and hemangioma-like lesion of the urinary bladder. [PDF]

open access: yesFront Pediatr
Pagani R   +11 more
europepmc   +1 more source

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