Results 141 to 150 of about 17,148 (192)
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Estimation and characterization of hamster leukocyte elastase
Biochemical Medicine, 1982Abstract A method is described for the preparation of granule extract from hamster polymorphonuclear leukocytes. The presence of elastase in this extract has been ascertained by the dual criteria of elastin solubilization and synthetic elastase substrate hydrolysis. The extract is also able to cleave one out of three cathepsin-G substrates.
C, Boudier, J G, Bieth
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Polymorphonuclear leukocyte elastase in patients with stroke
Acta Neurologica Scandinavica, 2009Polymorphonuclear leukocytes (PMNL) are involved in the pathogenesis of acute cerebral ischemia and atherosclerosis. Elastase is one of the proteolytic enzymes released by activated PMNL. We evaluated whether plasma levels of elastase-inhibitor complexes (EIC) are related to acute cerebral damage or with extension of carotid atherosclerosis in patients
N, Vila +3 more
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Annals of the New York Academy of Sciences, 2009
Poly(ADP‐ribose) polymerase‐1 (PARP‐1) uses NAD+ as a substrate to form ADP‐ribose. During apoptosis, caspases cleave PARP‐1 to avoid excessive NAD consumption. Because PARP‐1 is a key regulator of the activity of DNases involved in caspase‐dependent apoptosis, its cleavage is required to promote DNA degradation.
Chloé, Leprêtre +3 more
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Poly(ADP‐ribose) polymerase‐1 (PARP‐1) uses NAD+ as a substrate to form ADP‐ribose. During apoptosis, caspases cleave PARP‐1 to avoid excessive NAD consumption. Because PARP‐1 is a key regulator of the activity of DNases involved in caspase‐dependent apoptosis, its cleavage is required to promote DNA degradation.
Chloé, Leprêtre +3 more
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Enantioselective inhibition of human leukocyte elastase
Archives of Biochemistry and Biophysics, 1992(RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined.
Groutas, William C. +3 more
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Polymorphonuclear leukocyte cells and elastase in tears
Current Eye Research, 1997To characterize the effects that mode of sampling and overnight eye closure have on the nature of caseinolytic activity recovered in tear fluid.Reflex, open and closed (R, O and C) eye tear fluids were collected by microcapillary tubes or from the inferior formix by Schirmer strip.
M, Sakata +4 more
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Comparison of the Elastolytic Effects of Human Leukocyte Elastase and Porcine Pancreatic Elastase
Biochemical and Biophysical Research Communications, 1976Porcine and bovine elastins were digested by human leukocyte elastase and porcine pancreatic elastase. The enzymes showed similarities in the extent to which they digested elastin and the pattern and quantitative distribution of N-terminal amino acids in the digests.
R M, Senior +2 more
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Inhibitors of pancreatic and leukocyte elastase
Collection of Czechoslovak Chemical Communications, 1987The following alkylamides of ω-carboxyalkanoyldi- and tripeptides of the Ala-Pro or Ala-Ala-Pro sequence have been prepared: ethylamide-, propylamide-, and isobutylamide of 3-carboxypropionylalanyl-proline, ethylamide of 3-carboxypropionylalanyl-alanyl-proline and ethylamide-, propylamide, and isobutylamide of 4-carboxybutyrylalanyl-alanyl-proline. The
Evžen Kasafírek +3 more
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Reperfusion-induced leukocyte infiltration: role of elastase
American Journal of Physiology-Heart and Circulatory Physiology, 1990Polymorphonuclear leukocytes are known to accumulate in tissues subjected to ischemia and reperfusion. Studies on endothelial cell monolayers suggest that limited release of elastase plays an important role, via basement membrane degradation, in the leukocyte diapedesis and extravasation elicited by proinflammatory mediators.
B J, Zimmerman, D N, Granger
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Inhibition by Boswellic Acids of Human Leukocyte Elastase
The Journal of Pharmacology and Experimental Therapeutics, 1997Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene biosynthesis and exert potent anti-inflammatory effects. Screening for additional effects of boswellic acids on further proinflammatory pathways, we observed that acetyl-11-keto-beta-boswellic acid, an established direct, nonredox ...
H, Safayhi +3 more
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Repurposing a leukocyte elastase inhibitor for neuropathic pain
Nature Medicine, 2015Neuropathic pain is a debilitating condition affecting millions of people worldwide. A new study investigates mechanisms of neuropathic pain initiation and identifies a promising therapeutic currently used for acute respiratory distress syndrome that may also limit acute neuropathic pain.
Andy D, Weyer, Cheryl L, Stucky
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