Results 211 to 220 of about 33,574 (255)

[44] Leukocyte Elastase

1981
Publisher Summary This chapter presents the procedure for purification and assaying of leukocyte elastase. Leukocytes for use as starting material in the purification of leukocyte elastase are most conveniently obtained by leukapheresis of patients with chronic myeloid leukemia, or normal donors.
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Human leukocyte granule elastase: rapid isolation and characterization

Biochemistry, 1976
Human granulocytic elastases have been purified by a two-step procedure involving affinity chromatography of crude extracts of leukocytic granules on Sepharose-Trasylol, followed by ion-exchange chromatography on CM-cellulose to resolve the isoelastases. All of these enzymes were found to be glycoproteins with the carbohydrate content of the major form
R J, Baugh, J, Travis
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Interaction between human leukocyte elastase and chondroitin sulfate

Chemico-Biological Interactions, 1984
Chondroitin sulfate (Structum) interacts with human leukocyte elastase, a potent mediator of articular cartilage degradation, producing a partial inhibition of the enzyme activity (60% at saturation). Kinetically, the inhibition mechanism can be classified as simple intersecting, hyperbolic noncompetitive and is almost identical to that found earlier ...
A, Baici, P, Bradamante
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Human leukocyte elastase and cystic fibrosis

2003
Cystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America (Davis et al 1996; Rosenstein and Cutting, 1998). The defective gene was identified in 1989 by a team of investigators under the direction of Drs. Lap-Chee Tsui, John Riordan and Francis Collins (Kerem et al 1989; Riordan et al 1989; Rommens
André M. Cantin, Amélie Fournier, Richard Leduc   +2 more
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Repurposing a leukocyte elastase inhibitor for neuropathic pain

Nature Medicine, 2015
Neuropathic pain is a debilitating condition affecting millions of people worldwide. A new study investigates mechanisms of neuropathic pain initiation and identifies a promising therapeutic currently used for acute respiratory distress syndrome that may also limit acute neuropathic pain.
Andy D, Weyer, Cheryl L, Stucky
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[Human leukocyte elastase].

Pathologie-biologie, 1989
This article reviews some properties of human leucocyte elastase. This 30 kDa glycoprotein formed of 218 amino acid residues, is a serine proteinase which cleaves proteins at Val-X, Ala-X, Leu-X or Met-X bonds. Leucocyte elastase solubilizes fibrous elastin and also degrades other extracellular matrix proteins. It hydrolyses and inactivates a number of
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Polymorphonuclear Leukocyte-elastase in Crohn's Disease

Journal of Clinical Gastroenterology, 2000
In Crohn's disease (CD), labeled leukocyte scintigraphy results are highly correlated with radioendoscopic findings and the degree of histologic inflammation. We evaluated the correlation between leukocyte activity measured by two complementary methods. polymorphonuclear leukocyte (PMN)-elastase concentration and leukocyte scintigraphy.
R, Dhôte, P, Dhôte-Burger, T, Thevenot, J Y, Devaux, E, Beades, B, Richard, B, Christoforov   +6 more
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Platelet Elastase and Leukocyte Elastase are two Different Entities

Thrombosis and Haemostasis, 1977
Y, Legrand, J P, Caen, L, Robert, J L, Wautier   +3 more
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Elastase-2/Leukocyte Elastase

2013
Brice Korkmaz, Francis Gauthier
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Leukocyte Elastase

American Journal of Respiratory and Critical Care Medicine, 2001
W L, Lee, G P, Downey
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