Results 111 to 120 of about 241,803 (259)

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

The role of Th1/Th2 disbalanced immune response in the determination of clinical features of autoimmune diabetes mellitus

Сахарный диабет, 2011
Aim. To elucidate the role of Th1/Th2 polarization of immune response in LADA patients in the realization of the clinical phenotype of the disease. Materials and methods. 70 patients aged 21-61 (mean 41.3?1.0 yr) with DM diagnosed based on WHO criteria
Tatiana Vladimirovna Saprina, F E Lazarenko, T S Prokhorenko, N V Ryazantseva, Irina Nikolaevna Vorozhtsova   +4 more
doaj   +1 more source

TGF-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibility [PDF]

, 2010
Theileria parasites invade and transform bovine leukocytes causing either East Coast fever (T. parva), or tropical theileriosis (T. annulata). Susceptible animals usually die within weeks of infection, but indigenous infected cattle show markedly reduced
Regina Lizundia, Baumgartner, M, Lizundia, Regina, Janski, N., Glasgow, Weri, W, Werling, D, Bern, Switzerland, Werling, Dirk, Weitzmn, J B, Werling, D., Marie Chaussepied, Glass, Elizabeth, Glass Elizabeth J., Shiels, Brian R., Langsley, G, CNRS UM7216, Paris, Weir, W., Jensen, K., Langsley Gordon, Jensen, K, Jonathan B Weitzman, Weitzman, Jonathan, Chaussepied, Marie, Lizundia, R, Weitzman, Jonathan B., Shiels, Brian, Jensen, Kirsty, Gordon Langsley, Royal (Dick) School of Veterinary Studies, Elizabeth J. Glass, Janski, N, Dirk Werling, Paris-Descartes, Brian R Shiels, Natacha Janski, Jensen Kirsty, Janski, Natacha, Baumgartner, M., Chaussepied, M, Baumgartner, Martin, Langsley, G., Chaussepied, M., Glass, Elizabeth J., Martin Baumgartner, Janski Natacha, Weitzman Jonathan B., Weitzman, J.B., Jonathan B. Weitzman, Shiels, B.R., Shiels, B R, Werling Dirk, Edinburgh, Glass, E.J., Heussler, V.T., Paris-Diderot, Chaussepied Marie, Inserm, Paris, Elizabeth J Glass, Baumgartner Martin, Brian R. Shiels, Glass, E J, Lizundia Regina, Langsley, Gordon, Lizundia, R., Weir, William, Kirsty Jensen, Shiels Brian R., Weir William, William Weir   +69 more
core   +2 more sources

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Androgen binding sites in peripheral human mononuclear leukocytes of healthy males and females.

, 1994
Androgen binding sites have been identified in circulating human mononuclear leukocytes of healthy donors of both sexes. Cells were separated from blood samples on a Ficoll gradient and incubated with different concentrations of [3H]testosterone in the ...
BAUR S., ARMANINI, DECIO, MEURER M, LINDL U, KELLER U, KUHNLE U   +5 more
core   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Cytokine and Prostaglandin E2 Release from Leukocytes in Response to Metal Ions Derived from Different Prosthetic Materials: An In Vitro Study

, 2009
Cytokines produced by leukocytes in the periprosthetic membranes surrounding joint replacements have been implicated as causal agents in osteolysis and prosthetic loosening.
Liu, Hwa-Chang; Chang, Walter Hong-Shong; Lin, Feng-Huei; Lu, Kuan-How; Tsuang, Yang-Hwei; Sun, Jui-Sheng, 劉華昌;張恆雄;林峰輝;曾永輝;孫瑞昇   +1 more
core