Results 61 to 70 of about 241,803 (259)

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Macro- and microelements of blood mononuclear leukocytes in patients withpulmonary tuberculosis

Бюллетень сибирской медицины, 2007
In article the results of the analysis of changes of the contents macro- and microelements (К+, Ca2+, Fe2+, Cu2+, Mn2+, Zn2+, Mg2+, Al3+) in lymphocytes and monocytes of peripheral blood in patients with infiltrative drug-sensitive and drug-resistant ...
V. V. Novitsky, A. K. Strelis, O. I. Ourazova, T. A. Shilko, S. B. Tkachenko, I. Ye. Yesimova, O. V. Voronkova, V. A. Serebryakova, O. V. Filinyuk, Ye. V. Ivanova, O. V. Baranova   +10 more
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Regulation of cholesterol biosynthesis in sitosterolemia: effects of lovastatin, cholestyramine, and dietary sterol restriction.

Journal of Lipid Research, 1991
We investigated the effects of lovastatin, cholestyramine, and dietary sterol restriction on cholesterol synthesis and low density lipoprotein receptor function in freshly isolated mononuclear leukocytes from two unrelated sitosterolemic families.
LB Nguyen, M Cobb, S Shefer, G Salen, GC Ness, GS Tint   +5 more
doaj   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Surface LSP-1 Is a Phenotypic Marker Distinguishing Human Classical versus Monocyte-Derived Dendritic Cells

iScience, 2020
Summary: Human mononuclear phagocytes comprise several subsets of dendritic cells (DCs), monocytes, and macrophages. Distinguishing one population from another is challenging, especially in inflamed tissues, owing to the promiscuous expression of ...
Sandrine Moutel, Anne Beugnet, Aurélie Schneider, Bérangère Lombard, Damarys Loew, Sebastian Amigorena, Franck Perez, Elodie Segura   +7 more
doaj   +1 more source

β�-Adrenoceptor Changes in Mononuclear Leukocytes During Pregnancy

, 1995
Leukocyte β-adrenoceptors mirror similar receptors in the uterus. This study examined changes in β2-adrenoceptors and in cAMP production during pregnancy using peripheral mononuclear leukocytes isolated from 17 pregnant women and 5 nonpregnant controls ...
Rice, Peter J., Nwosu, Uchenna C.
core   +1 more source

Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass analysis [PDF]

, 2005
Angiotensin II ( Ang II) is the major vasoactive component of the renin- angiotensin system. Several components of the renin- angiotensin system have been demonstrated in different tissues.
TOLLE, M, GOBOM, J, Vanholder, R., Giebing, G, KARADOGAN, S, SCHLUTER, H, Jankowski, V, HENNING, L, Schönfelder, G., Krakow, A., van der Giet, M., Vanholder, R, Gustavsson, Niklas, Karadogan, S., Webb, J., JANKOWSKI, J, Jankowski, Vera, Tölle, M., Schlüter, H., Vanholder, Raymond, ZIDEK, W, Gustavsson, Niklas,, SCHONFELDER, G, Henning, L., Gustavsson, N., KRAKOW, A, GUSTAVSSON, N, Zidek, W., Gobom, J., HILGERS, KF, Lehrach, H., Hilgers, K., WEBB, J, GIEBING, N, Jankowski, V., Lund University., Giebing, G., VAN DER GIET, M, LEHRACH, H   +38 more
core   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

A comparison of delipidated sera used in studies of sterol synthesis by human mononuclear leukocytes.

Journal of Lipid Research, 1979
Sterol synthesis in human mononuclear leukocytes is stimulated by delipidated serum. Synthesis in media containing serum delipidated by three different methods is compared.
H R Slater, F W Robertson
doaj   +1 more source