Results 101 to 110 of about 403,834 (312)

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins

Frontiers in Neuroscience, 2019
Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the ...
Danielle N. Edwards, Danielle N. Edwards, Gregory J. Bix, Gregory J. Bix   +3 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Features of tissue healing of laparotomy wounds after cesarean section in obesity

Известия высших учебных заведений. Поволжский регион: Медицинские науки
Background. Recently, the number of cesarean section deliveries has increased, which increases the risk of postoperative complications. One of the important risk factors is obesity, which significantly complicates the healing of laparotomy wounds.
E.A. Davydova, A.P. Vlasov, A.E. Markina, T.I. Vlasova, D.G. Sardaeva   +4 more
doaj   +1 more source

Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model

Frontiers in Cellular Neuroscience, 2019
BackgroundThe brain is protected by the blood-brain barrier (BBB), constituted by endothelial cells supported by pericytes and astrocytes. In Alzheimer’s disease a dysregulation of the BBB occurs since the early phases of the disease leading to an ...
Simona Federica Spampinato, Sara Merlo, Evelina Fagone, Mary Fruciano, Cristina Barbagallo, Takashi Kanda, Yasuteru Sano, Michele Purrello, Carlo Vancheri, Marco Ragusa, Marco Ragusa, Maria Angela Sortino   +11 more
doaj   +1 more source

Psoriasis and Leukocyte Chemotaxis.

Journal of Investigative Dermatology, 1987
Transepidermal migration of leukocytes, with resultant formation of microscopic or macroscopic sterile subcorneal pustules is a phenomenon characteristically noted in psoriasis and related sterile pustular dermatoses. It is natural to assume the presence of potent neutrophil chemotactic substances in the subcorneal portion of the lesional epidermis ...
Tagami, Hachiro, Iwatsuki, Keiji, Takematsu, Hideaki   +2 more
openaire   +2 more sources

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

First-in-human infection imaging with 89Zr-labelled leukocytes and comparison of scan quality with [99mTc]Tc-HMPAO-labelled leukocytes [PDF]

DATA AVAILABITY STATEMENT: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.INTRODUCTION: Nuclear medicine infection imaging is routinely performed with the use of leukocytes ...
Ebenhan, Thomas, Gutta, Aadil, Parsoo, Aman, Kahts, Maryke, More, Andrew, Aras, Omer, Summers, Beverley, Nemutaduni, Phumudzo, Ndlela, Akhona, Zeevaart, Jan Rijn, Sathekge, Mike Machaba   +10 more
core   +3 more sources

Andrographolide Inhibits Expression of NLPR3 Inflammasome in Canine Mononuclear Leukocytes

Animals
Inflammasomes are multiprotein complexes that trigger processes through caspase-1 activation, leading to the maturation of proinflammatory cytokines, such as IL-1β and IL-18.
Alejandro Albornoz, Bibiana Pardo, Sofia Apaoblaza, Claudio Henriquez, Javier Ojeda, Benjamín Uberti, Juan Hancke, Rafael A. Burgos, Gabriel Moran   +8 more
doaj   +1 more source

HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection

BMC Cardiovascular Disorders, 2003
Background Statins effectively lower blood cholesterol and the risk of cardiovascular death. Immunomodulatory actions, independent of their lipid-lowering effect, have also been ascribed to these compounds.
Vamvakopoulos Joannis E, Green Colin
doaj   +1 more source