Results 81 to 90 of about 403,834 (312)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Proliferative activity of bone marrow cells of rats under the influence of biologically active substances of a medical leech

Regulatory Mechanisms in Biosystems, 2017
Hirudotherapy has been used in medicine since time immemorial. The advantage of this type of treatment is that the bite of a leech has a restorative effect on the entire body.
R. F. Aminov, A. K. Frolov
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Effects of Antifungal pretreatment on the susceptibility of Candida albicans to human leukocytes

, 1997
The aim of this work was to measure the susceptibility of Candida albicans pretreated for 2 or 6 h with fluconazole (Flu), ketoconazole (Ktz), amphotericin B (AmB) and 5-fluorocyto-sine (5-Fc) to the fungicidal action of human polymorphic leukocytes. The
García Esteban, María Teresa, Prieto José, Lima José Enrique, Mínguez Mínguez, Fernando A.   +3 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Flow Cytometry Evaluation of Blood-Cell-Bound Surface FVIII in Hemophilia A and Thrombosis

Cells
Hemophilia A (HA) is associated with FVIII coagulation insufficiency or inactivity leading to excessive bleeding. Elevated FVIII, on the contrary, is associated with thrombophilia, thrombosis, myocardial infarctions, and stroke.
Anjud Al-Mohannadi, Reem Mohammed Yahia, Hani Bibawi, Che-Ann Lachica, Watfa Ahmed, Igor Pavlovski, Giusy Gentilcore, Elkhansa Elbukhari Elgaali, Anila Ejaz, Areeg Ahmed, Mohammed Elanbari, Zainab Awada, Mohammed J. Al-Kubaisi, Muhammad Elnaggar, Ayman Saleh, Chiara Cugno, Sara Deola   +16 more
doaj   +1 more source

Cytokine and Prostaglandin E2 Release from Leukocytes in Response to Metal Ions Derived from Different Prosthetic Materials: An In Vitro Study

, 2009
Cytokines produced by leukocytes in the periprosthetic membranes surrounding joint replacements have been implicated as causal agents in osteolysis and prosthetic loosening.
Liu, Hwa-Chang; Chang, Walter Hong-Shong; Lin, Feng-Huei; Lu, Kuan-How; Tsuang, Yang-Hwei; Sun, Jui-Sheng, 劉華昌;張恆雄;林峰輝;曾永輝;孫瑞昇   +1 more
core  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

STUDY OF THE DISTRIBUTION OF LARVAE IN MUSCLES AND SOME PERIPHERAL BLOOD PARAMETERS OF GALLUS GALLUS IN EXPERIMENTAL INFECTION WITH TRICHINELLA PSEUDOSPIRALIS

Siberian Journal of Life Sciences and Agriculture
Background. Poultry meat, the main host of the capsule-free species, is the most popular among the population. The consumer willingly buys both meat of chickens, laying hens, ducks, turkeys and geese, and hog game.
Olga B. Zhdanova, Olga V. Chasovskikh
doaj   +1 more source

Apoptosis- and survival-related gene mRNA profile in peripheral blood leukocytes in children with acute EBV infectious mononucleosis

Инфекция и иммунитет, 2020
Acute EBV-associated mononucleosis develops mainly in children and in patients with functionally impaired immune system. Consequently, it may result in developing secondary immunodeficiency, neoplasms as well as diverse alterations in cell-mediated ...
N. A. Sakharnov, O. V. Utkin, E. N. Filatova, D. I. Knyazev, N. B. Presnyakova   +4 more
doaj   +1 more source