Results 161 to 170 of about 375,888 (308)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

From Hero to Hijacker: Autophagy's Double Life in Immune Patrols and Cancer Escape. [PDF]

Cells
Garampon F, Claude-Taupin A.
europepmc   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Genomic characterization of host gene alterations in Theileria annulata-transformed leukocytes. [PDF]

Commun Biol
Dandasena D, Suresh A, Budhwar R, Godwin J, Singh S, Subudhi M, A VM, T A, Roy S, Bhandari V, Sharma P.   +10 more
europepmc   +1 more source

peripheral blood leukocytes of mouse Effects of somatic extract and culture filtrate of fusarium solani on

, 2004
M R Aghamirian, Farideh Zaini, Hassan Hashemi   +2 more
openalex   +1 more source

Administration of 13-Cis-Retinoic Acid to Dairy Cattle. 2. Phenotype of Blood Leukocytes and Production of Immunoglobulin

, 1995
S.T. Franklin, J.W. Young, R.L. Horst, Brian J. Nonnecke   +3 more
openalex   +1 more source

Azurophil leukocyte granules [letter] [PDF]

, 1984
G Kelenyi
openalex   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Regulating white blood cell activity through the novel universal receptive system. [PDF]

Sci Rep
Tetz V, Kardava K, Vecherkovskaya M, Khodadadi-Jamayran A, Tsirigos A, Tetz G.   +5 more
europepmc   +1 more source

Leukocyte [PDF]

, 2020
openaire   +1 more source