Results 251 to 260 of about 594,733 (360)

PTf‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei, Yichun Pan, Jie Zhai, Tongqing Li, Yuxin Zhou, Sheyu Zhang, Juan Wei, Qian Hu, Xueying Liu, Lu Guo, Weizhu Wu, Yong Wei, Qin Wu, Weihong Tan   +13 more
wiley   +1 more source

Blood perfusion through ventricular assist devices induces erythrocytes to interact with leukocytes. [PDF]

Biochem Biophys Rep
Foster KM, El Banayosy AM, Azartash-Namin Z, Coghill P, Long JW, O'Rear E, Setiadi H.   +6 more
europepmc   +1 more source

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

Advanced Science, EarlyView.
This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee, Rut Tejero, Nathaniel Silvia, Anirudh Sattiraju, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou, Guohao Dai   +10 more
wiley   +1 more source

Editorial: Community series in intravital microscopy imaging of leukocytes, volume II

Frontiers in Immunology
Connie H. Y. Wong, Craig N. Jenne, Elzbieta Kolaczkowska   +2 more
doaj   +1 more source

PMN recruitment in inflammatory lung injury models follows classical transendothelial migration paradigms requiring PECAM-1 and CD99. [PDF]

Am J Physiol Lung Cell Mol Physiol
Haynes ME, Arias E, Sullivan DP, Muller WA.   +3 more
europepmc   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Clarifying Blood Indices in Patients With Ovarian Cancer.

JMIR Mhealth Uhealth
Lian C, Fan Y, Li J.
europepmc   +1 more source

Microvascular immunity is organ-specific and remodeled after kidney injury in mice. [PDF]

Nat Commun
Rixen R, Schütz P, Walter C, Hüchtmann B, Van Marck V, Heitplatz B, Varghese J, Varga G, Foell D, Pap T, Pavenstädt H, Buscher K.   +11 more
europepmc   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

Validation and clinical implementation of cerebrospinal fluid C-reactive protein for the diagnosis of bacterial meningitis: a prospective diagnostic accuracy study. [PDF]

Lancet Reg Health Eur
Olie SE, Staal SL, Groeneveld NS, Schotman HHM, Bodilsen J, Nielsen H, Bijlsma MW, van de Beek D, Brouwer MC.   +8 more
europepmc   +1 more source