Results 181 to 190 of about 17,815 (221)

Update on Progressive Multifocal Leukoencephalopathy

Current Neurology and Neuroscience Reports, 2012
Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, opportunistic viral infection of the central nervous system that is mainly seen in the context of AIDS and certain monoclonal immune-suppressive therapies. The causative agent, a polyoma virus, named JC virus infects only humans and there is no animal model for PML.
Israel, Steiner, Joseph R, Berger
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Progressive multifocal leukoencephalopathy

Journal of Neuroimmunology, 2011
Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the opportunistic infections. It is observed in patients with HIV infection, lymphoid malignancies, after organ- and stem cell transplantations and more recently in the context of ...
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Viruses and Progressive Multifocal Leukoencephalopathy

New England Journal of Medicine, 1972
There has recently been an increasing interest in the relation between viruses and chronic degenerative diseases of the brain. Within the past few years, measles virus has been found to be associated with subacute sclerosing panencephalitis and transmissible agents have been isolated from patients with Kuru and Creutzfeldt—Jakob disease (spongiform ...
P H, Black, M S, Hirsch
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Progressive multifocal leukoencephalopathy and natalizumab

Journal of Neurology, 2011
Natalizumab (TYSABRI(®)), a specific α4-integrin antagonist, is approved as a second-line treatment of relapsing-remitting MS (RRMS) patients who fail therapy with interferons or as first-line treatment of patients with highly active relapsing-remitting disease. Since the market introduction of natalizumab as a monotherapy in July of 2006, 111 cases of
Kerstin, Hellwig, Ralf, Gold
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[Progressive multifocal leukoencephalopathy].

Der Nervenarzt, 2016
Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV). Due to the elevated risk in patients treated with natalizumab for multiple sclerosis (MS) and also treatment with other biologicals for different indications, the relevance of PML has increased in recent years.
Warnke C, Wattjes MP, Adams O, Hartung HP, Martin R, Weber T, Stangel M   +6 more
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Progressive Multifocal Leukoencephalopathy

New England Journal of Medicine, 1961
IN the course of the regular post-mortem examination of the brains of patients coming to autopsy at the Massachusetts General Hospital, my attention has been called in recent years to an unusual disorder of the cerebral white matter with distinctive features unfamiliar to me and my colleagues from our own experience or that of others.
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Natalizumab and Progressive Multifocal Leukoencephalopathy

New England Journal of Medicine, 2005
The Brief Reports on natalizumab were referred to Biogen Idec, the manufacturer, which offers the following response: After learning of one confirmed and one suspected case of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab, Biogen Idec and Elan quickly notified the Food and Drug Administration (FDA) and other ...
Burt, Adelman, Alfred, Sandrock, Michael A, Panzara   +2 more
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Progressive Multifocal Leukoencephalopathy in AIDS

AIDS Patient Care, 1991
CASE PRESENTATION —John Williams, MD A 42-YEAR-OLD bisexual, white man presented complaining of progressive memory loss, confusion, and difficulty speaking for 1 week. The patient had been diagnosed with acquired immunodeficiency syndrome (AIDS) a year earlier when he developed cutaneous Kaposi's sarcoma.
R E, Chaisson, D E, Griffin
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Progressive multifocal leukoencephalopathy in HIV

International Journal of STD and AIDS, 1997
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by infection of oligodendrocytes by JC virus. As patients with HIV survive longer with severe immunodeficiency, the incidence of PML is rising.
M, Sadler, M R, Nelson
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The EEG in progressive multifocal leukoencephalopathy

Electroencephalography and Clinical Neurophysiology, 1969
Abstract One original case and two previously reported cases of progressive multifocal leukoencephalopathy (PML) are reviewed, with emphasis on their EEG features. In one the diagnosis could be made and confirmed by brain biopsy prior to death. The EEG findings in these three cases and those in other cases reported in the literature suggest the value
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