Results 191 to 200 of about 711,937 (246)

Progressive multifocal leukoencephalopathy in multiple myeloma

European Journal of Haematology, 2022
Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by reactivation of the JC virus in the context of immune suppression such as HIV, malignancy, and certain ...
Brian Hoeynck, A. Cohen, E. Stadtmauer, S. Susanibar-Adaniya, D. Vogl, A. Waxman, M. Bardsley, S. Le, Lexis LaMaestra, A. Garfall   +9 more
semanticscholar   +1 more source

Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

New England Journal of Medicine, 2019
Background Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain infection that is caused by the JC virus and is typically fatal unless immune function can be restored.
I. Cortese, P. Muranski, Yoshimi Enose-Akahata, S. Ha, Bryan R. Smith, M. Monaco, C. Ryschkewitsch, E. Major, J. Ohayon, M. Schindler, E. Beck, L. Reoma, S. Jacobson, D. Reich, A. Nath   +14 more
semanticscholar   +1 more source

Progressive Multifocal Leukoencephalopathy

Neurologic Clinics, 1984
PML is a progressive opportunistic infection of the CNS caused by a commonly occurring virus that may become manifest in the context of reduced host resistance in persons of any age. The authors review the disease and its causes, including a discussion of treatment attempts and differential diagnoses.
B R, Brooks, D L, Walker
openaire   +2 more sources

Progressive Multifocal Leukoencephalopathy

Journal of Neuroscience Nursing, 1982
A 32-year-old man had biopsy-proven progressive multifocal leukoencephalopathy (PML) and long-standing sarcoidosis. Treatment with several courses of cytarabine failed, and the patient died of the neurologic disease. Reports of therapeutic experiences in PML are summarized.
A, Minnick, A J, Oleson
openaire   +4 more sources

Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients

Multiple Sclerosis, 2020
Dimethyl fumarate (DMF), a fumaric acid with antioxidant and immunomodulatory properties, is among the most commonly used oral therapies for relapsing multiple sclerosis (MS).
A. Jordan, Jennifer Yang, Caitlyn J Fisher, M. Racke, Y. Mao-Draayer   +4 more
semanticscholar   +1 more source

Progressive Multifocal Leukoencephalopathy

Radiology, 1976
The radionuclide, radiographic and pathologic findings in a patient with progressive multifocal leukoencephalopathy were correlated. Radionuclide imaging demonstrated the largest two of the many lesions observed at pathology. On repeated studies, one of the lesions developed a "doughnut" sign due to central necrosis. Cerebral angiography disclosed only
J, Kirsh, L, Rosenthall, M H, Finlayson, R, Wee   +3 more
openaire   +2 more sources

Progressive Multifocal Leukoencephalopathy

Archives of Internal Medicine, 1963
Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease apparently resulting from the selective destruction of oligodendrocytes by papovaviruses. The pathology and pathogenesis of PML are distinct from those of the other slow infections of the human nervous system.
R F, JOHNSTON, R A, GREEN, J T, HEADINGTON   +2 more
openaire   +2 more sources

Progressive multifocal leukoencephalopathy

Current Infectious Disease Reports, 2001
Progressive multifocal leukoencephalopathy is a subacute demyelinating disease that occurs in patients with defects in cell-mediated immunity, including those with AIDS and lymphoproliferative disorders. It is caused by reactivation of JC virus (JCV), which infects 70% to 90% of the population by adulthood, but remains latent in normal hosts.
Anna R., Thorner, Joel T., Katz
openaire   +2 more sources

Progressive multifocal leukoencephalopathy

Journal of Neuroimmunology, 2011
Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the opportunistic infections. It is observed in patients with HIV infection, lymphoid malignancies, after organ- and stem cell transplantations and more recently in the context of ...
openaire   +3 more sources

Progressive Multifocal Leukoencephalopathy

Archives of Ophthalmology, 1959
Astrom, Mancall, and Richardson1have recently directed attention to progressive multifocal leukoencephalopathy, a previously unrecognized neuropathological entity. Visual symptoms have been prominent in this disorder. As no cases have been reported in the ophthalmologic literature, the following instance of progressive multifocal leukoencephalopathy ...
openaire   +2 more sources