Results 71 to 80 of about 21,234 (200)

Reirradiation: Standards, challenges, and patient‐focused strategies across tumor types

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 630-666, November/December 2025.
Abstract Reirradiation (reRT), defined as administering a course of radiation therapy to a specific area previously irradiated, is an evolving treatment strategy for locoregionally recurrent cancer that offers significant potential and poses inherent challenges.
Arnaud Beddok, Jonas Willmann, Anna Embring, Ane L. Appelt, Panagiotis Balermpas, Kevin Chua, J. Isabelle Choi, Bernice Simone Elger, Dorota Gabrys, Peter Hoskin, Maximilian Niyazi, David Pasquier, Kelly Paradis, Orit Kaidar‐Person, Corien Plaisier, Nicole C. Schmitt, Conor E. Steuer, Juliette Thariat, Sue S. Yom, Philip Poortmans, Eliana Vasquez Osorio, Nicolaus Andratschke   +21 more
wiley   +1 more source

The Precuneus Region Drives Brain Network Changes in Tremor‐Dominant Parkinson's Disease: Insights from a Morphological Causal Analysis

MedComm, Volume 6, Issue 11, November 2025.
We uncovered a unique morphological progression pattern in tremor‐dominant Parkinson's disease. Based on this, a machine‐learning model combining cortical volume features with clinical assessments was developed to reliably predict deep brain stimulation (DBS) outcomes.
Moxuan Zhang, Siyu Zhou, Pengda Yang, Huizhi Wang, Jinli Ding, Xiaobo Wang, Xuzhu Chen, Chaonan Zhang, Anni Wang, Yuan Gao, Qiang Liu, Yuchen Ji, Yin Jiang, Lin Shi, Chunlei Han, Zhong Yang, Tao Feng, Jianguo Zhang, Fangang Meng   +18 more
wiley   +1 more source

Immune profiling of a patient with alemtuzumab-associated progressive multifocal leukoencephalopathy

Multiple Sclerosis, 2019
A 31-year-old woman affected by multiple sclerosis (MS) experienced generalized tonic–clonic seizures 2 months after the second alemtuzumab cycle. Positive JC virus (JCV)-DNA in cerebrospinal fluid (CSF) and lesion iconography at magnetic resonance ...
S. Gerevini, R. Capra, D. Bertoli, A. Sottini, L. Imberti   +4 more
semanticscholar   +1 more source

Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the Central Nervous System—A Multicenter Cohort Study in 163 Patients

Annals of Neurology, Volume 98, Issue 4, Page 883-893, October 2025.
Objective The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. Methods In a retrospective, observational cohort study, we analyzed 163 adult patients who met the diagnostic criteria for PACNS.
Anna Lena Fisse, Nadine Bonberg, Carolin Beuker, Claudia Pfeuffer, Andreas Heidenreich, Christina Krüger, Milani Deb‐Chatterji, Jana Becker, Stefan T. Gerner, Clemens Küpper, Louisa Nitsch, Roxane‐Isabelle Kestner, Lars Udo Krause, Juliane Herm, Alexander Katalinic, André Karch, Ralf Gold, Heinz Wiendl, Wolf‐Rüdiger Schäbitz, Gabor C. Petzold, Waltraud Pfeilschifter, Marius Ringelstein, Thorsten R. Doeppner, Lars Kellert, Hagen B. Huttner, Markus Kraemer, Tim Magnus, Karl Georg Haeusler, Heike Minnerup, Jens Minnerup   +29 more
wiley   +1 more source

COL4A1‐Related Leukoencephalopathy and Microangiopathy: A Case Series of Two Palestinian Siblings

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT We report two Palestinian siblings with a pathogenic COL4A1 mutation, presenting with congenital cataracts, seizures, developmental delay, and antenatal intracerebral hemorrhages. Despite sharing the same genetic variant, they exhibited striking phenotypic variability.
Thkra Meshal, Amal M. Shawabka, Kareem lbraheem, Rosol Iwaiwi, Nissreen E. Thafer, Jinan H. Afana, Ahmad G. Hammouri, Osama Atawneh   +7 more
wiley   +1 more source

HIV-Associated Progressive Multifocal Leukoencephalopathy: A Case Study

Acta Medica Indonesiana, 2023
Progressive multifocal leukoencephalopathy (PML) is a rare, life-threatening, infectious, lytic, demyelinating disease that results from reactivation of the virulent JC polyomavirus (JCV) “major opportunistic infection” in immunosuppressed individuals ...
Elsayed Abed, Ahmed Farag El-adawey, Mohamed Hamed Rashad, Ahmed Essmat, Mohammed Ali, Ahmed Hassan Elsheshiny, Abdel-Ghaffar Fayed, Fathy Elbaz, Mahmoud Galal Ahmed, Zohreh Abna, Shaimaa Sayed Khater   +10 more
doaj   +2 more sources

Successful Treatment of Facial Pseudolymphoma With Intravenous Rituximab: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Intravenous rituximab demonstrated significant efficacy in treating a case of refractory cutaneous pseudolymphoma that failed multiple conventional therapies, including corticosteroids, hydroxychloroquine, methotrexate, and biologics. The patient, a 42‐year‐old man, initially developed erythematous, nodular lesions on the face following dental
Elham Behrangi, Nastaran Khodakarim, Shila Amiri, Seyyedeh Tahereh Rahimi, Neda Safarzadeh, Alireza Jafarzadeh   +5 more
wiley   +1 more source

Bilateral Middle Cerebellar Peduncle Lesions in Wernicke's Encephalopathy

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Bilateral MCP lesions have a diverse etiology, ranging from treatable conditions to diseases with poor prognosis. Although uncommon, Wernicke's encephalopathy (WE) should be considered in the differential diagnosis of MCP lesions, particularly in malnourished patients or those with chronic alcoholism who present with ataxia, encephalopathy, or
Tomonobu Fukuda, Takashi Katsube, Hiro Tamegai, Naoki Omori, Shun Aritake, Takuya Nemoto, Ryo Kataoka, Yoshihito Aoki, Kenichi Iwasa, Yukie Kanai, Atsushi Nagai   +10 more
wiley   +1 more source

Pembrolizumab for progressive multifocal leukoencephalopathy due to primary immunodeficiency

Neurology: Neuroimmunology & Neuroinflammation, 2019
Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating disease of the CNS, which develops almost exclusively in immunocompromised patients and is caused by JC virus (JCV), a common polyomavirus.1 So far, treatment efficacy is ...
C. Küpper, Johanna Heinrich, K. Kamm, Veit L Bücklein, S. Rothenfusser, A. Straube   +5 more
semanticscholar   +1 more source

Clinical Experience With Biologic Disease‐Modifying Therapy in Relapsing–Remitting Multiple Sclerosis: A Case Report and Review of Literature

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Biological agents are highly effective in preventing/minimizing disability related to multiple sclerosis. However, in resource‐limited countries, the diagnosis and management of multiple sclerosis are limited by social and structural determinants of health.
Pandaramparambil Saidu Nazneen, Thinley Dorji, Sonam Yangzom, R. Vijayalakshmi Natarajan   +3 more
wiley   +1 more source