Results 71 to 80 of about 711,937 (246)

Progressive multifocal leukoencephalopathy - Epidemiology, immune response, clinical differences, treatment

, 2019
Progressive multifocal leukoencephalopathy (PML) is a severe disease of the central nervous system with very high mortality. It is caused by the JC virus with high seroprevalence, at up to 80%.
Havlíčková, Kateřina, Husa, Petr, Snopková, Svatava, Volfová, Pavlína, Svačinka, Radek, Fašaneková, Lenka, Mihalčin, Matúš, Štourač, Petr, Snopek, Petr   +8 more
core   +1 more source

Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report

Frontiers in Immunology, 2022
Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression ...
Nicolas Lambert, Nicolas Lambert, Majdouline El Moussaoui, Caroline Ritacco, Martin Moïse, Martin Moïse, Astrid Paulus, Philippe Delvenne, Frédéric Baron, Frédéric Baron, Bernard Sadzot, Pierre Maquet   +11 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy after fingolimod treatment

Neurology, 2018
Objective We describe the characteristics of the 15 patients with fingolimod-associated progressive multifocal leukoencephalopathy (PML) identified from the Novartis data safety base and provide risk estimates for the disorder.
J. Berger, B. Cree, B. Greenberg, B. Hemmer, B. Ward, Victor M. Dong, M. Merschhemke   +6 more
semanticscholar   +1 more source

Germline Genetic Risk Variants for Progressive Multifocal Leukoencephalopathy

Frontiers in Neurology, 2020
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disorder of the brain caused by reactivation of the JC virus (JCV), a polyomavirus that infects at least 60% of the population but is asymptomatic or results in benign symptoms in ...
P. S. Eis, Christopher Donald Bruno, T. Richmond, I. Koralnik, Barbara A. Hanson, E. Major, Christina R. Chow, H. Hendel-Chavez, B. Stankoff, J. Gasnault, Y. Taoufik, E. Hatchwell   +11 more
semanticscholar   +1 more source

Progressive multifocal leukoencephalopathy therapy [PDF]

Journal of NeuroVirology, 2014
Progressive multifocal leukoencephalopathy (PML) is caused by the JC virus in the setting of chronic immune deficiency. Developing therapy has been challenged by the rarity of the disease as well as the complexity of patients in whom it develops. Several small trials directed at presumptive antiviral therapies have failed to show convincing clinical ...
openaire   +2 more sources

Adverse Reactions Identified after Approval of Novel Medicines: Analysis of 339 New Molecular Entities and Therapeutic Biologics

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1120-1128, October 2026.
Postmarketing safety surveillance data identify safety issues not identified in preapproval clinical trials. We describe the frequency of new safety issues overall and by labeling section and the relationship of the most commonly added safety issues with the cumulative number of prescriptions dispensed via retail pharmacies.
Ellen Pinnow, Brendan Day, Esther H. Zhou, Corinne Woods, Nana Dwumfour, Jenni Y. Lee, Ilynn Bulatao, Sanae Cherkaoui, Manish Kalaria, Sonja Brajovic, Nabila Sadiq, Farideh Sistani, Maggie Lee, Grace Chai, Gerald Dal Pan   +14 more
wiley   +1 more source

Allogeneic BK Virus–Specific T Cells for Progressive Multifocal Leukoencephalopathy

New England Journal of Medicine, 2018
&NA; JC virus, the cause of progressive multifocal leukoencephalopathy (PML), and the BK virus are genetically similar and share sequence homology in immunogenic proteins.
M. Muftuoglu, A. Olson, D. Marin, Saira S. Ahmed, V. Mulanovich, S. Tummala, T. Chi, A. Ferrajoli, I. Kaur, Li Li, R. Champlin, E. Shpall, K. Rezvani   +12 more
semanticscholar   +1 more source

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses

European Journal of Immunology, Volume 56, Issue 10, October 2026.
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand, Samy Taouli, Dorian McIlroy   +2 more
wiley   +1 more source

Progressive Multifocal Leukoencephalopathy Associated with Infliximab

, 2016
A 69-year-old female with seropositive rheumatoid arthritis presented with progressive cognitive decline following treatment with infliximab and methotrexate. Cranial MRI showed non-enhancing white matter signal abnormality consistent with demyelination
C Holroyd, D Wallis, L Sammut
core   +1 more source

Progressive multifocal leukoencephalopathy in a child with acquired immunodeficiency syndrome (AIDS) Leucoencefalopatia multifocal progressiva em uma criança com síndrome da imunodeficiênda adquirida

Arquivos de Neuro-Psiquiatria, 1997
Progressive multifocal leukoencephalopathy is a rare viral-induced demyelinating disease associated to immunodeficiency. A 10-year-old boy with AIDS is reported, who developed subacute cerebellar signs and symptoms with multiple cranial nerve involvement
Alexandra Prufer de Q.C. Araujo, Heloisa S. Pereira, Ricardo H. Oliveira, Ana C. Frota, José C. Esperança, Francisco Duarte   +5 more
doaj   +1 more source