Results 51 to 60 of about 43,456 (236)

MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist’s Perspective [PDF]

Journal of Clinical and Diagnostic Research, 2017
Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current
Geetika Sindhwani, Manali Arora, Vishal Dhirenbhai Thakker, Abhinav Jain   +3 more
doaj   +1 more source

Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men, Hui Li, Zhuoxin Guo, Bin Qin, Hengfang Ruan, Ruipeng Cai, Bingjun Zhang, Aimin Wu, Lei Wei, Yongqiang Dai, Haiyan Li, Zhengqi Lu   +11 more
wiley   +1 more source

Diagnostic Insighhts Into JC Virus-Infected Glial Cells: Intraoperative Cytopathological Analysis of Dot-Shaped Inclusions Associated With PML-NBs. [PDF]

Cytopathology
This is the first case report describing the diagnostic value of dot‐shaped inclusions associated with promyelocytic leukaemia nuclear bodies (PML‐NBs) to define JC virus–infected glial cells in an intraoperative cytopathological diagnosis for progressive multifocal leukoencephalopathy (PML).
Ujihira N, Doi H, Shishido-Hara Y.
europepmc   +2 more sources

NIHSS Scores in Ischemic Small Vessel Disease: A Study in CADASIL [PDF]

, 2012
Background: The National Institutes of Health Stroke Scale (NIHSS) is widely used to measure neurological deficits, evaluate the effectiveness of treatment and predict outcome in acute ischemic stroke.
Allili, Nassira, Chabriat, Hugues, Dichgans, Martin, Duering, Marco, Herve, Dominique, Jouvent, Eric, Yao, Ming   +6 more
core   +1 more source

The Leukodystrophies HBSL and LBSL—Correlates and Distinctions

Frontiers in Cellular Neuroscience, 2021
Aminoacyl-tRNA synthetases (ARSs) accurately charge tRNAs with their respective amino acids. As such, they are vital for the initiation of cytosolic and mitochondrial protein translation. These enzymes have become increasingly scrutinized in recent years
Annapoorani Muthiah, Gary D. Housley, Matthias Klugmann, Dominik Fröhlich   +3 more
doaj   +1 more source

Posterior reversible encephalopathy syndrome (PRES) after bevacizumab therapy for metastatic colorectal cancer. [PDF]

, 2018
Posterior reversible encephalopathy syndrome (PRES) is an increasingly recognizable neuro-clinical syndrome. Clinical and neurological manifestations of PRES include hypertension, headache, encephalopathy, seizures, and symmetrical white matter changes ...
Ghani, Ali, Hamid, Mohsin, Lashari, MD, Bilal, Malik, Faizan, Micaily, Ida, Sarwar, MD, Usman   +5 more
core   +2 more sources

A homozygous mutation of alanyl‐transfer RNA synthetase 2 in a patient of adult‐onset leukodystrophy: A case report and literature review

Brain and Behavior, 2019
Introduction Leukodystrophy is a group of hereditary leukoencephalopathies predominantly affecting the white matter. Multiple genes and mutations have been reported to be associated with this disorder.
Jian‐Yong Wang, Song‐Fang Chen, Hong‐Qiu Zhang, Meng‐Yan Wang, Jian‐Hong Zhu, Xiong Zhang   +5 more
doaj   +1 more source

COVID-19-associated leukoencephalopathy in the absence of severe hypoxia with subsequent improvement: a case report

BMC Infectious Diseases, 2022
Background Several cases of coronavirus disease 2019 (COVID-19)-associated leukoencephalopathy have been reported. Although most cases involve hypoxia, the pathophysiological mechanism and neurologic outcomes of COVID-19-associated leukoencephalopathy ...
Hiroki Kojima, Naoya Sakamoto, Atsushi Kosaka, Masayoshi Kobayashi, Mitsuo Amemiya, Takuya Washino, Yusuke Kuwahara, Takuto Ishida, Mayu Hikone, Satoshi Miike, Tatsunori Oyabu, Sentaro Iwabuchi, Fukumi Nakamura-Uchiyama   +12 more
doaj   +1 more source

Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease [PDF]

Alzheimers Dement
Abstract INTRODUCTION Myelin is pivotal for signal transfer and thus cognition. Cerebral small vessel disease (cSVD) is primarily associated with white matter (WM) lesions and diffusion changes; however, myelin alterations and related cognitive impairments in cSVD remain unclear.
Denecke J, Dewenter A, Lee J, Franzmeier N, Valentim C, Kopczak A, Dichgans M, Pirpamer L, Gesierich B, Duering M, Ewers M.   +10 more
europepmc   +2 more sources

A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment. [PDF]

, 2017
Megalencephaly and macrocephaly present with a head circumference measurement 2 standard deviations above the age-related mean. However, even if pathologic events resulting in both megalencephaly and macrocephaly may coexist, a distinction between these ...
Corsello G, Falsaperla R, Parano E, Pavone P, Praticò AD, Rizzo R, Ruggieri M   +6 more
core   +1 more source