Results 51 to 60 of about 66,344 (289)

Data_Sheet_1_Plasma lipidomic profiling of thiopurine-induced leukopenia after NUDT15 genotype-guided dosing in Chinese IBD patients.docx

, 2023
IntroductionThiopurines, azathiopurine (AZA) and mercaptopurine (6-MP) have been regularly used in the treatment of inflammatory bowel disease (IBD). Despite optimized dosage adjustment based on the NUDT15 genotypes, some patients still discontinue or ...
Kang Chao (3471287), Xiang Gao (4077), Min Huang (161268), Pinjin Hu (598948), Ting Yang (189879), Xueding Wang (1908130), Jing Mao (148640), Xia Zhu (396327), Pan Li (335711), Lulu Qin (16450410), Zhanhua Hu (16450407)   +10 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Effect of "Fresmin S" on leukopenia [PDF]

, 1965
"Fresmin S", injectable solution, was used for patients with leukopenia caused by anticancer agents and the following results were obtained. 1) In view of the results of the present ex periment, concomitant use of "Fresmin S" with the anticancer agent is
江藤, 耕作, 飯田, 収
core  

Estimates cumulative incidence of Leukopenia.

, 2015
Kaplan-Meier estimates show that the cumulative incidence of leukopenia was higher in the patients with 94C>A compared with those without 94C>A.
Shigeo Koido (390312), Keisuke Saito (516747), Shinichiro Takami (794284), Toshifumi Ohkusa (390330), Hiroko Kobayashi (794285), Kan Uchiyama (390324), Takahiro Kubota (794282), Shunichi Odahara (390318), Zensho Ito (794283)   +8 more
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Letermovir for Cytomegalovirus Prophylaxis in Lung Transplant Patients with Valganciclovir-Induced Leukopenia

Transplantology, 2021
Cytomegalovirus (CMV) prophylaxis with valganciclovir is the standard of practice in most transplant centers, but treatment-related leukopenia can limit valganciclovir’s use.
Arindam Singha, Pamela K. Burcham, April Logan, Zeinab El Boghdadly, Molly M. Howsare, David R. Nunley, Mark E. Lustberg, Brian C. Keller   +7 more
doaj   +1 more source

Tacrolimus, a forgotten agent in kidney transplant leukopenia [PDF]

, 2013
Leukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single ...
Rocha, G., Dias, L., Santos, T., Pedroso, S., Martins, L., Silva, H., Freitas, C., Castro-Henriques, A., Aguiar, P., Cabrita, A., Cabral, J., Almeida, M., Azevedo, P.   +12 more
core   +1 more source

Data_Sheet_1_Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population.docx

, 2022
Background and AimsThiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with ...
Ruey Terng Ng (13201872), Ida Normiha Hilmi (13201887), Xin-Hui Khoo (13201866), Kee Seang Chew (13201875), Alex Hwong-Ruey Leow (9545207), Shin Yee Wong (2886920), Nik Razima Wan Ibrahim (13201869), Way Seah Lee (13016730), Raja Affend Raja Ali (13201881), Shahreedhan Shahrani (13201884), Zhi Qin Wong (13201878)   +10 more
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Liposomal Ellagic Acid Alleviates Cyclophosphamide-Induced Toxicity and Eliminates the Systemic Cryptococcus neoformans Infection in Leukopenic Mice

Pharmaceutics, 2021
Cryptococcus neoformans infections rose sharply due to rapid increase in the numbers of immunocompromised individuals in recent years. Treatment of Cryptococcosis in immunocompromised persons is largely very challenging and hopeless.
Masood Alam Khan, Arif Khan, Mohd Azam, Khaled S. Allemailem, Faris Alrumaihi, Ahmad Almatroudi, Fahad A. Alhumaydhi, Faizul Azam, Shaheer Hasan Khan, Syeda Fauzia Farheen Zofair, Sumbul Ahmad, Hina Younus   +11 more
doaj   +1 more source