Results 61 to 70 of about 64,598 (305)

Pharmacokinetics, Effectiveness and Safety of Certolizumab Pegol in Children and Adolescents With Active Juvenile Idiopathic Arthritis: 9+‐Year Results From a Multicenter, Open‐Label Study

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients aged 2 to 17 years with ...
Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Laura Shaughnessy, Saori Shimizu, Paulette Williams, Rocío Lledó‐García, Gauri Utturkar, Baran Ufuktepe, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto, the Paediatric Rheumatology International Trials Organisation (PRINTO); the Pediatric Rheumatology Collaborative Study Group (PRCSG), Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Alberto Martini, Daniel L. Lovell, Nicolino Ruperto   +52 more
wiley   +1 more source

Characteristics of Leukopenia.

, 2015
UC, ulcerative colitis; CD, Crohn’s Disease; 5ASA, 5-aminosalicylic acid; IFX, infliximabTPMT, Thiopurine S-methyltransferase; ITPA, Inosine triphosphate pyrophosphatase6-TGN, 6-thioguanine nucleotide.
Shigeo Koido (390312), Keisuke Saito (516747), Shinichiro Takami (794284), Toshifumi Ohkusa (390330), Hiroko Kobayashi (794285), Kan Uchiyama (390324), Takahiro Kubota (794282), Shunichi Odahara (390318), Zensho Ito (794283)   +8 more
core   +1 more source

Hemodialysis leukopenia and complement function with different dialyzers. [PDF]

, 1983
The relationship between leukopenia and the complement system during hemodialysis was re-examined by studying not only the in vivo effects of four different dialyzer membranes (cellulose hydrate, cuprophan, cellulose acetate, and polyacrilonitrile) on ...
Massai, Graziella, Candi P, Sasdelli M, Mario Ricci, Stefania Favilla, Passaleva A, Ricci M., Alberto Amadori, AMADORI, ALBERTO, Mauro Sasdelli, Sasdelli, Mauro, Angelo Passaleva, Massai G, Candi, Paolo, Paolo Candi, Favilla, Stefania, Graziella Massai, Ricci, Mario, Passaleva, Angelo, Favilla S   +19 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Risk of hematologic malignancies following herpes zoster after COVID-19: a global cohort study

Frontiers in Medicine
IntroductionHerpes zoster (HZ) has been reported as a potential post-viral complication in individuals recovering from COVID-19, possibly due to virus-induced immune dysregulation.
Chien-Lin Lu, Chien-Lin Lu, Joshua Wang, Joshua Wang, Ching-Liang Ho, Yan-Jun Wu, Kuo-Cheng Lu, Kuo-Cheng Lu, Chung-Chi Yang, Chung-Chi Yang, Chung-Chi Yang, Chung-Chi Yang   +11 more
doaj   +1 more source

Tacrolimus, a forgotten agent in kidney transplant leukopenia [PDF]

, 2013
Leukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single ...
Rocha, G., Dias, L., Santos, T., Pedroso, S., Martins, L., Silva, H., Freitas, C., Castro-Henriques, A., Aguiar, P., Cabrita, A., Cabral, J., Almeida, M., Azevedo, P.   +12 more
core   +1 more source

The role of oxidative biomarkers in feline pan- leukopenia [PDF]

, 2022
Feline Pan-leukopenia is an important deadly gastrointestinal disease of cats. It is mostly prevalent in kittens with declining maternal antibodies as well as unvaccinated cats.
Khoshvaghti, A, Nojaba, E
core  

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Sarcopenia Is Associated With Hematologic Toxicity During Chemoradiotherapy in Patients With Anal Carcinoma

Frontiers in Oncology, 2020
PurposeSarcopenia, defined as a loss of muscle mass and quality, has been associated with impaired oncological outcome and treatment toxicities in several malignancies.
Daniel Martin, Daniel Martin, Daniel Martin, Daniel Martin, Jens von der Grün, Jens von der Grün, Jens von der Grün, Claus Rödel, Claus Rödel, Claus Rödel, Claus Rödel, Emmanouil Fokas, Emmanouil Fokas, Emmanouil Fokas, Emmanouil Fokas   +14 more
doaj   +1 more source