Results 61 to 70 of about 66,344 (289)

XDH genotypes through gene–gene interactions with NUDT15 affect azathioprine-induced leukopenia in Chinese patients: Supplementary materials

, 2022
Aim: To investigate whether genotypes of XDH, GMPS and MOCOS were associated with azathioprineinduced adverse drug reaction (ADR) and had the gene–gene interactions with NUDT15 rs116855232 to induce leukopenia.
Sichao Huang (4031558), Zhiyong Wen (752457), Xinbo Ai (3342902), Jiajian Qian (13187592), Jiquan Liu (2602252), Xiaomin Zhang (136250)   +5 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Lithium‐related adverse drug reactions in children: A case–control study comparing lithium to second‐generation antipsychotics in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to improve the understanding of lithium's safety profile by analysing the frequency and distribution of reported adverse drug reactions (ADRs) compared to second‐generation antipsychotics (SGAs). Methods Individual case safety reports from VigiBase (1968–October 2023) involving individuals older than 2 years, with lithium or SGAs ...
Lisa T. Ringeling, Ravish N. Gangapersad, Lillian Lieuw, Patrick C. Souverein, Eibert R. Heerdink, Pilar Garcia‐Gomez, Manon H. J. Hillegers, Birgit C. P. Koch, Bram Dierckx   +8 more
wiley   +1 more source

Risk of hematologic malignancies following herpes zoster after COVID-19: a global cohort study

Frontiers in Medicine
IntroductionHerpes zoster (HZ) has been reported as a potential post-viral complication in individuals recovering from COVID-19, possibly due to virus-induced immune dysregulation.
Chien-Lin Lu, Chien-Lin Lu, Joshua Wang, Joshua Wang, Ching-Liang Ho, Yan-Jun Wu, Kuo-Cheng Lu, Kuo-Cheng Lu, Chung-Chi Yang, Chung-Chi Yang, Chung-Chi Yang, Chung-Chi Yang   +11 more
doaj   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

From bodyweight to biomarkers: Season‐associated metabolic, endocrine and haematological shifts in breeding stallions

Equine Veterinary Journal, EarlyView.
Abstract Background Breeding stallions are subjected to sustained seasonal metabolic, endocrine, and immune demands requiring systemic energy engagement. Prospective longitudinal data in the same individuals are limited. Objectives To screen adaptive responses of breeding stallions of clinical relevance through longitudinal characterisation of temporal
Maria Grazia Cappai, Morrone Sarah, Senes Alice, Taras Andrea, Biggio Giampaolo, Cherchi Raffaele   +5 more
wiley   +1 more source

Food Safety Management and Mycotoxins Nexus: A Systematic Review of Mycotoxins Toxicity, Detoxification, Nutritional Impacts, and Economic Importance

Food Safety and Health, EarlyView.
The graphical abstract illustrates the interconnected relationship between food safety management, mycotoxin toxicity, and detoxification strategies, highlighting how preventive measures across the food chain can minimize mycotoxin contamination and reduce adverse health effects in humans/animals.
Chinaza Godswill Awuchi
wiley   +1 more source

Obinutuzumab-induced acute thrombocytopenia and leukopenia in ANCA-associated glomerulonephritis: case report and literature review

Frontiers in Immunology
Obinutuzumab is a humanized type II anti-CD20 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity. It is widely used in B-cell malignancies and is increasingly being explored in autoimmune diseases such as lupus nephritis. The main
Yiming Jin, Yiqi Huang, Xiaomiao He
doaj   +1 more source

In Vitro Leukoagglutination: A Rare Hematological Cause of Spurious Leukopenia [PDF]

, 2017
Leukopenia secondary to leukocytic agglutination is caused by an ethylene diamine tetra acetic acid (EDTA) which may appear in both benign and malignant states.
Sadia Sultan, Syed Muhammad Irfan
core