Results 51 to 60 of about 98,896 (358)

The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes

Frontiers in Pharmacology, 2022
The ER stress and Unfolded Protein Response (UPR) component inositol-requiring enzyme 1α (IRE1α) has been linked to inflammation and lipid mediator production.
Xiao Tang, Tarvi Teder, Bengt Samuelsson, Jesper Z. Haeggström   +3 more
doaj   +1 more source

Conducting retrospective impact analysis to inform a medical research charity’s funding strategies: The case of Asthma UK [PDF]

, 2013
© 2013 Hanney et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Amanda Watt, AR Jadad, British Thoracic Society and Scottish Intercollegiate Guidelines Network, British Thoracic Society Scottish Intercollegiate Guidelines Network, Canadian Academy of Medical Sciences, CE Brightling, D Cooksey, E Nason, E Xystrakis, GK Scadding, House of Lords Science and Technology Committee, J Bott, LA Laitinen, LB Bacharier, Leanne Metcalf, LJ Tata, M Buxton, M Buxton, M Thomas, MA Berry, National Institute for Health Research, P Adam, PA Wark, PE Christie, PE Christie, PJ Jose, PM O’Byrne, PV Dicpinigaitis, R Banzi, R Smith, S Hanney, S Hanney, S Hanney, S Hanney, S Saglani, S Walker, S Wooding, SR Durham, Stephen R Hanney, T Pang, Teresa H Jones, TH Lee, UK Evaluation Forum, WJ Oortwijn, WL Oldfield   +44 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Promising Effects of Montelukast for Critically Ill Asthma Patients via a Reduction in Delirium

Pharmaceuticals
Background: Montelukast (MTK), a potent antagonist of cysteinyl leukotriene receptor 1, has shown therapeutic promise for the treatment of neuropsychiatric disorders.
Yuan Li, Meilin Zhang, Shengnan Zhang, Guoping Yang   +3 more
doaj   +1 more source

Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells

Pharmacology Research & Perspectives, 2019
5‐lipoxygenase (5‐LO) catalyzes the biosynthesis of leukotrienes, potent lipid mediators involved in inflammatory diseases, and both 5‐LO and the leukotrienes are validated therapeutic targets.
Maroua Mbarik, Samuel J. Poirier, Jérémie Doiron, Ayyoub Selka, David A. Barnett, Marc Cormier, Mohamed Touaibia, Marc E. Surette   +7 more
doaj   +1 more source

Aspirin-Exacerbated Asthma

Allergy, Asthma & Clinical Immunology, 2008
This review focuses on aspirin-exacerbated asthma (AEA). The review includes historical perspective of aspirin, prevalence, pathogenesis, clinical features and treatment of AEA.
Varghese Mathew, Lockey Richard F
doaj   +1 more source

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo [PDF]

, 2013
Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined1,2. Once outside the
Afonso, P., Angermann, B., Germain, R., Kastenmüller, W., Lämmermann, T., Parent, C., Wang, J.   +6 more
core   +2 more sources

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

Steroids in pediatric eosinophilic esophagitis [PDF]

, 2014
Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic corticosteroids.
Contreras, Emily M., Gupta, Sandeep K.
core   +1 more source

Role of Leukotrienes and Leukotriene Modifiers in Asthma

Pharmaceuticals, 2010
Leukotrienes (LTs), including cysteinyl LTs (CysLTs) and LTB4, are potent lipid mediators that are pivotal in the pathophysiology of asthma phenotypes. At least two receptor subtypes for CysLTs – CysLT1 and CysLT2 – have been identified. Most of the pathophysiological effects of CysLTs in asthma, including increased airway smooth muscle activity ...
openaire   +3 more sources